김기현 (성균관대학교 약학대학) | 상위피인용논문 > 한빛사

상위피인용논문

조회57

성균관대학교 약학대학

CV File 577 kb

J. Ginseng Res., Jul 2018, 42 (3) | https://doi.org/10.1016/j.jgr.2017.03.011 Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions

Ki Hyun Kim ^{1 †}, Dahae Lee^{1 †}, Hye Lim Lee², Chang-Eop Kim², Kiwon Jung ^{3 *}, Ki Sung Kang ^{2 *}

¹School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea.
²College of Korean Medicine, Gachon University, Seongnam, Republic of Korea.
³Institute of Pharmaceutical Sciences, College of Pharmacy, CHA University, Sungnam, Republic of Korea.

^†These authors contributed equally

^*Corresponding authors: correspondence to Kiwon Jung or Ki Sung Kang

Abstract

In recent years, several therapeutic drugs have been rationally designed and synthesized based on the novel knowledge gained from investigating the actions of biologically active chemicals derived from foods, plants, and medicinal herbs. One of the major advantages of these naturalistic chemicals is their ability to interact with multiple targets in the body resulting in a combined beneficial effect. Ginseng is a perennial herb (Araliaceae family), a species within the genus Panax, and a highly valued and popular medicinal plant. Evidence for the medicinal and health benefits of Panax ginseng and its components in preventing neurodegeneration has increased significantly in the past decade. The beneficial effects of P. ginseng on neurodegenerative diseases have been attributed primarily to the antioxidative and immunomodulatory activities of its ginsenoside components. Mechanistic studies on the neuroprotective effects of ginsenosides revealed that they act not only as antioxidants but also as modulators of intracellular neuronal signaling and metabolism, cell survival/death genes, and mitochondrial function. The goal of the present paper is to provide a brief review of recent knowledge and developments concerning the beneficial effects as well as the mechanism of action of P. ginseng and its components in the treatment and prevention of neurodegenerative diseases.

논문정보

형식Review Paper
게재일2018년 07월 (BRIC 등록일 2025-09-10)
연구진국내 연구진
분야 바이오·의료융합 > 뇌인지과학
피인용횟수120회 이상 인용된 논문

댓글 작성 로그인

CV 열람하기

연락처 보기