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한국생명공학연구원

Cancers, 2020 Sep 14;12(9):2622 | https://doi.org/10.3390/cancers12092622 Epigenetic Associations between lncRNA/circRNA and miRNA in Hepatocellular Carcinoma

Tae-Su Han ^1,†, Keun Hur ^2,†, Hyun-Soo Cho^1,*and Hyun Seung Ban ^1,*

¹Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
²Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.

^†These authors contributed equally

^*Corresponding authors: correspondence to Hyun-Soo Cho or Hyun Seung Ban

Abstract

The three major members of non-coding RNAs (ncRNAs), named microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play an important role in hepatocellular carcinoma (HCC) development. Recently, the competing endogenous RNA (ceRNA) regulation model described lncRNA/circRNA as a sponge for miRNAs to indirectly regulate miRNA downstream target genes. Accumulating evidence has indicated that ceRNA regulatory networks are associated with biological processes in HCC, including cancer cell growth, epithelial to mesenchymal transition (EMT), metastasis, and chemoresistance. In this review, we summarize recent discoveries, which are specific ceRNA regulatory networks (lncRNA/circRNA-miRNA-mRNA) in HCC and discuss their clinical significance.

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