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서울대학교, 현 서울과학기술대학교

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Adv. Healthc. Mater., Dec 2017, 6 (23) | https://doi.org/10.1002/adhm.201700612 Biomimetic Materials and Fabrication Approaches for Bone Tissue Engineering

Hwan D. Kim ¹, Sivashanmugam Amirthalingam ², Seunghyun L. Kim³, Seunghun S. Lee³, Jayakumar Rangasamy ², Nathaniel S. Hwang^{1 3 4 *}

¹School of Chemical and Biological Engineering, The Institute of Chemical Processes, Seoul National University, Seoul, 151-742, Republic of Korea.
²Centre for Nanosciences and Molecular Medicine, Amrita University, Kochi, 682041, India.
³Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 151-742, Republic of Korea.
⁴The BioMax Institute of Seoul National University, Seoul, 151-742, Republic of Korea.

^*Corresponding author: correspondence to Nathaniel S. Hwang

Abstract

Various strategies have been explored to overcome critically sized bone defects via bone tissue engineering approaches that incorporate biomimetic scaffolds. Biomimetic scaffolds may provide a novel platform for phenotypically stable tissue formation and stem cell differentiation. In recent years, osteoinductive and inorganic biomimetic scaffold materials have been optimized to offer an osteo-friendly microenvironment for the osteogenic commitment of stem cells. Furthermore, scaffold structures with a microarchitecture design similar to native bone tissue are necessary for successful bone tissue regeneration. For this reason, various methods for fabricating 3D porous structures have been developed. Innovative techniques, such as 3D printing methods, are currently being utilized for optimal host stem cell infiltration, vascularization, nutrient transfer, and stem cell differentiation. In this progress report, biomimetic materials and fabrication approaches that are currently being utilized for biomimetic scaffold design are reviewed.

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