Dinesh K. Patel (강원대학교) | 상위피인용논문 > 한빛사

상위피인용논문

조회108

강원대학교

Carbohydr. Polym., Apr 01 2022, 281 S0144-8617(21)01464-8 | https://doi.org/10.1016/j.carbpol.2021.119077 3D-printable chitosan/silk fibroin/cellulose nanoparticle scaffolds for bone regeneration via M2 macrophage polarization

Dinesh K. Patel^{a 1}, Sayan Deb Dutta ^{b 1}, Jin Hexiu ^{c 1}, Keya Ganguly ^b, Ki-Taek Lim ^{a b *}

^aInstitute of Forest Science, Kangwon National University, Chuncheon 24341, Republic of Korea
^bDepartment of Biosystems Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea
^cSchool of Stomatology, Capital Medical University, Beijing 100050, China

¹Equal contributions.
^*Corresponding author: correspondence to Ki-Taek Lim

Abstract

Biopolymers-induced immune microenvironment exhibited prominent effects on bone regeneration. Osteo-immunomodulatory responses of cellulose nanoparticles incorporated chitosan hydrogel scaffolds have not yet been reported. The objective of this study was to monitor the synergistic effects of silk fibroin and cellulose nanoparticles on the immune-modulatory behavior of chitosan biopolymer scaffolds. 3D-printed biodegradable cellulose nanoparticles-reinforced chitosan/silk fibroin (CS/SF/CNPs) scaffolds were fabricated and characterized by different spectroscopic techniques. The improved rheological and recovery strength was observed in CS/SF/CNPs hydrogels than pure polymer hydrogels. A significant shift from M1 → M2 macrophages polarization occurred in the CS/SF/CNPs scaffolds treated groups than the control after 3 days of incubation, showing its immune-modulatory potential. Osteo-immunomodulatory effects of the fabricated scaffolds were analyzed on human bone marrow-derived mesenchymal stem cells (hBMSCs), with macrophages-derived conditioned media (M-CM). Enhanced bone regeneration was observed in the calvaria defect rat model, indicating that the fabricated scaffolds are promising materials for bone-healing applications.

논문정보

형식Research article
게재일2022년 04월 (BRIC 등록일 2025-05-08)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 다학제 융합/복합
피인용횟수60회 이상 인용된 논문

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