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상위피인용논문
상위피인용논문
- 조회486
Acta Biomaterialia, May 2011, 7 (5) | https://doi.org/10.1016/j.actbio.2011.01.006
Analysis on migration and activation of live macrophages on transparent flat and nanostructured titanium
Soyoung Lee a 1, Jungil Choi b 1, Sangwon Shin c, Yeon-Min Im d, Jonghan Song c, Sang Soo Kang b,Tae-Hyun Nam d,Thomas J. Webster e, Sang-Hyun Kim a *, Dongwoo Khang d *
aDepartment of Pharmacology, Kyungpook National University Medical School, Daegu, 700-422, South Korea
bDepartment of Anatomy, Institute of Health Science and School of Medicine, Gyeongsang National University, Jinju, 660-701, South Korea
cNanomaterials Analysis Center, Korea Institute of Science and Technology, Seoul, 136-791, South Korea
dCenter for NMBE and School of Nano and Advanced Materials Science and Engineering, Gyeongsang National University, Jinju, 660-701, South Korea
eSchool of Engineering and Department of Orthopaedics, Brown University, Providence, RI 02912, USA
bDepartment of Anatomy, Institute of Health Science and School of Medicine, Gyeongsang National University, Jinju, 660-701, South Korea
cNanomaterials Analysis Center, Korea Institute of Science and Technology, Seoul, 136-791, South Korea
dCenter for NMBE and School of Nano and Advanced Materials Science and Engineering, Gyeongsang National University, Jinju, 660-701, South Korea
eSchool of Engineering and Department of Orthopaedics, Brown University, Providence, RI 02912, USA
1These authors contributed equally.
*Corresponding authors: correspondence to Sang-Hyun Kim or Dongwoo Khang
*Corresponding authors: correspondence to Sang-Hyun Kim or Dongwoo Khang
Abstract
The immunotoxicity of implanted nanostructured titanium is a paramount issue for vascular, dental and orthopedic applications. However, it has been unclear whether implanted surface nanostructures can inhibit or aggrevate inflammatory responses. Herein, macrophage activation, as evidence of migration, on transparent flat and nanostructured titanium correlated with pro-inflammatory protein synthesis and cytokine release. Through the real-time monitoring of initial cytoskeleton variations, this study identified that macrophage movement was restricted on nanostructured titanium compared to flat titanium surfaces. Furthermore, nanostructured titanium elicited secretion of fewer pro-inflammatory enzyme molecules and cytokines, as well as reduced nitric oxide production. All results collectively indicated that initial macrophage activation can be mitigated by nanoscale surface topography alone, without modification of surface chemistry or stiffness.
논문정보
- Research article
- 2011년 05월 (BRIC 등록일 2025-02-14)
- 국내 연구진
- 의약학 > 면역의학
- 120회 이상 인용된 논문
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