이원융 (가천대학교, 현 원광대학교) | 상위피인용논문 > 한빛사

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이원융Won-Yung Lee

가천대학교, 현 원광대학교

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Biomolecules, Aug 13 2019, 9 (8) 362 | https://doi.org/10.3390/biom9080362 The methodological trends of traditional herbal medicine employing network pharmacology

Won-Yung Lee ¹, Choong-Yeol Lee ¹, Youn-Sub Kim ^2,* and Chang-Eop Kim^1,*

¹Department of Physiology, College of Korean Medicine, Gachon University, Seongnam 13120, Korea

²Department of Anatomy-Pointology, College of Korean Medicine, Gachon University, Seongnam 13120, Korea

^*Corresponding authors: correspondence to Youn-Sub Kim or Chang-Eop Kim

Abstract

Natural products, including traditional herbal medicine (THM), are known to exert their therapeutic effects by acting on multiple targets, so researchers have employed network pharmacology methods to decipher the potential mechanisms of THM. To conduct THM-network pharmacology (THM-NP) studies, researchers have employed different tools and databases for constructing and analyzing herb-compound-target networks. In this study, we attempted to capture the methodological trends in THM-NP research. We identified the tools and databases employed to conduct THM-NP studies and visualized their combinatorial patterns. We also constructed co-author and affiliation networks to further understand how the methodologies are employed among researchers. The results showed that the number of THM-NP studies and employed databases/tools have been dramatically increased in the last decade, and there are characteristic patterns in combining methods of each analysis step in THM-NP studies. Overall, the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was the most frequently employed network pharmacology database in THM-NP studies. Among the processes involved in THM-NP research, the methodology for constructing a compound-target network has shown the greatest change over time. In summary, our analysis describes comprehensive methodological trends and current ideas in research design for network pharmacology researchers.

논문정보

형식Research article
게재일2019년 08월 (BRIC 등록일 2024-06-25)
연구진국내 연구진
분야 의약학 > 한의학
피인용횟수120회 이상 인용된 논문

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