정선재 (서울대학교 의과대학, 현 연세대학교 의과대학) | 상위피인용논문 > 한빛사

상위피인용논문

조회522

서울대학교 의과대학, 현 연세대학교 의과대학

CV File

Br. J. Psychiatry, Jul 2017, 211 (1) | https://doi.org/10.1192/bjp.bp.116.186726 Association between body size, weight change and depression: systematic review and meta-analysis

Sun Jae Jung, Hyung-taek Woo, Sooyoung Cho, Kyounghoon Park, Seokhun Jeong, Yu Jin Lee, Daehee Kang and Aesun Shin ^*

Sun Jae June, MD, PhD, Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea.

Hyuna-taek woo, MD, Sooyouna Cho, MS, Kyounahoon Park, MD, Seokhun Jeong, MD, Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

Yu Jin Lee, MD, PhD, Department of Psychiatry, Seoul National University Hospital, Seoul, Korea.

Daehee Kang, MD, PhD, Department of Biomedical Science, Department of Preventive Medicine, Seoul National University College of Medicine and cancer Research Institute, Seoul National University, Seoul, Korea.

Aesun Shin, MD, PhD, Department of Preventive Medicine, Seoul National University College of Medicine and cancer Research Institute, Seoul National University, Seoul, Korea.

^*Corresponding author: correspondence to Aesun Shin

Abstract

Background

The association between body size, weight change and depression has not been systematically summarised, especially for individuals who are underweight.

Aims

To conduct a systematic review and a meta-analysis to examine the association between indices of body size, weight change and depression.

Method

A total of 183 studies were selected. Fully adjusted hazard ratios (HRs) or odds ratios (ORs) were extracted. A total of 76 studies contributed to data synthesis with a random-effect model, and subgroup analyses were conducted to evaluate the effect of potential moderators.

Results

In cohort studies, underweight at baseline increased the risk of subsequent depression (OR = 1.16, 95% CI 1.08–1.24). Overweight (BMI 25–29.9 kg/m²) showed no statistically significant relationship with depression overall; however, the subgroup analyses found different results according to gender (men: OR = 0.84, 95% CI 0.72–0.97, women: OR = 1.16, 95% CI 1.07–1.25). In cross-sectional designs, obesity with BMI >40kg/m²showed a greater pooled odds ratio than obesity with BMI >30kg/m².

Conclusions

Both underweight and obesity increase the risk of depression. The association between overweight and depression differs by gender.

논문정보