박준호 (서울대학교 병원, 현 차의과대학교) | 상위피인용논문 > 한빛사

상위피인용논문

조회984

박준호Joonho Park

서울대학교 병원, 현 차의과대학교

Sci. Rep., 2020 Dec 29;10(1):22418 | https://doi.org/10.1038/s41598-020-80120-8 In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

Joonho Park ¹, Hyeyoon Kim ¹, SoYeon Kim ², Yeonjae Kim ³, Jee‑Soo Lee ⁴, Kisoon Dan ¹, Moon‑Woo Seong ^4* & Dohyun Han ^1*

¹Proteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, 71 Daehak‑ro, Seoul, Republic of Korea.
²Department of Laboratory Medicine, National Medical Center, Seoul, Korea.
³Department of Infectious Disease, National Medical Center, Seoul, Korea.
⁴Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak‑ro, Seoul, Republic of Korea

*Corresponding author: correspondence to Moon‑Woo Seong or Dohyun Han

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over forty million patients worldwide. Although most coronavirus disease 2019 (COVID-19) patients have a good prognosis, some develop severe illness. Markers that define disease severity or predict clinical outcome need to be urgently developed as the mortality rate in critical cases is approximately 61.5%. In the present study, we performed in-depth proteome profiling of undepleted plasma from eight COVID-19 patients. Quantitative proteomic analysis using the BoxCar method revealed that 91 out of 1222 quantified proteins were differentially expressed depending on the severity of COVID-19. Importantly, we found 76 proteins, previously not reported, which could be novel prognostic biomarker candidates. Our plasma proteome signatures captured the host response to SARS-CoV-2 infection, thereby highlighting the role of neutrophil activation, complement activation, platelet function, and T cell suppression as well as proinflammatory factors upstream and downstream of interleukin-6, interleukin-1B, and tumor necrosis factor. Consequently, this study supports the development of blood biomarkers and potential therapeutic targets to aid clinical decision-making and subsequently improve prognosis of COVID-19.

논문정보

형식Research article
게재일2020년 12월 (BRIC 등록일 2023-06-21)
연구진국내 연구진
분야 의약학 > 인체시스템의학
피인용횟수60회 이상 인용된 논문

댓글 작성 로그인

CV 열람하기

연락처 보기