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J. Control. Release, Volume 238, 28 September 2016 | https://doi.org/10.1016/j.jconrel.2016.06.015 A 3D-printed local drug delivery patch for pancreatic cancer growth suppression

Hee-Gyeong Yi ^{a 1}, Yeong-Jin Choi ^{b 1}, Kyung Shin Kang ^c, Jung Min Hong ^c, Ruby Gupta Pati ^a, Moon Nyeo Park ^a, In Kyong Shim ^d, Chan Mi Lee ^d, Song Cheol Kim ^{d e}, Dong-Woo Cho ^a

^aDepartment of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk, Republic of Korea
^bDivision of Integrative Biosciences and Biotechnology, POSTECH, Pohang, Kyungbuk, Republic of Korea
^cDepartment of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
^dBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea
^eDepartment of Surgery, University of Ulsan Colleague of Medicine & Asan Medical Center, Seoul, Republic of Korea

¹These authors contributed equally to this work.
Corresponding author: correspondence to Song Cheol Kim or Dong-Woo Cho

Abstract

Since recurrence and metastasis of pancreatic cancer has a worse prognosis, chemotherapy has been typically performed to attack the remained malignant cells after resection. However, it is difficult to achieve the therapeutic concentration at the tumor site with systemic chemotherapy. Numerous local drug delivery systems have been studied to overcome the shortcomings of systemic delivery. However, because most systems involve dissolution of the drug within the carrier, the concentration of the drug is limited to the saturation solubility, and consequently cannot reach the sufficient drug dose. Therefore, we hypothesized that 3D printing of a biodegradable patch incorporated with a high drug concentration would provide a versatile shape to be administered at the exact tumor site as well as an appropriate therapeutic drug concentration with a controlled release. Here, we introduce the 3D-printed patches composed of a blend of poly(lactide-co-glycolide), polycaprolactone, and 5-fluorouracil for delivering the anti-cancer drug in a prolonged controlled manner and therapeutic dose. 3D printing technology can manipulate the geometry of the patch and the drug release kinetics. The patches were flexible, and released the drug over four weeks, and thereby suppressed growth of the subcutaneous pancreatic cancer xenografts in mice with minimized side effects. Our approach reveals that 3D printing of bioabsorbable implants containing anti-cancer drugs could be a powerful method for an effective local delivery of chemotherapeutic agents to treatment of cancers.

논문정보

형식Research article
게재일2016년 09월 (BRIC 등록일 2023-06-02)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 의료기기
피인용횟수120회 이상 인용된 논문

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