상위피인용논문
- 조회432
Yongwoo Jang1,2†, Minseok Kim3† and Sun Wook Hwang3,4*
1Department of Psychiatry and Program in Neuroscience, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.
2Department of Biomedical Engineering, Hanyang University, Seoul 04763, South Korea.
3Department of Biomedical Sciences, Korea University, Seoul 02841, South Korea.
4Department of Physiology, College of Medicine, Korea University, Seoul 02841, South Korea.
Yongwoo Jang and Minseok Kim contributed equally to this work.
Corresponding author: Correspondence to Sun Wook Hwang.
Abstract
Arachidonic acid-derived prostaglandins not only contribute to the development of inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of the peripheral somatosensory system, contributing to pain exacerbation. Peripheral tissues undergo many forms of diseases that are frequently accompanied by inflammation. The somatosensory nerves innervating the inflamed areas experience heightened excitability and generate and transmit pain signals. Extensive studies have been carried out to elucidate how prostaglandins play their roles for such signaling at the cellular and molecular levels. Here, we briefly summarize the roles of arachidonic acid-derived prostaglandins, focusing on four prostaglandins and one thromboxane, particularly in terms of their actions on afferent nociceptors. We discuss the biosynthesis of the prostaglandins, their specific action sites, the pathological alteration of the expression levels of related proteins, the neuronal outcomes of receptor stimulation, their correlation with behavioral nociception, and the pharmacological efficacy of their regulators. This overview will help to a better understanding of the pathological roles that prostaglandins play in the somatosensory system and to a finding of critical molecular contributors to normalizing pain.
논문정보
- Review Paper
- 2020년 01월 (BRIC 등록일 2023-01-17)
- 국내(교신)+국외 연구진
- 60회 이상 인용된 논문
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