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Neurobiol. Aging, Volume 35, Issue 6, June 2014, Pages 1286-1292 | https://doi.org/10.1016/j.neurobiolaging.2014.01.003 Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

Sung Hoon Baik 1, Moon-Yong Cha 1, Young-Min Hyun 2, Hansang Cho 3, Bashar Hamza 3, Dong Kyu Kim 1, Sun-Ho Han 1, Heesun Choi 1, Kyung Ho Kim 1, Minho Moon 1, Jeewoo Lee 4, Minsoo Kim 5, Daniel Irimia 3, Inhee Mook-Jung 6

1Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
3BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
4Department of Pharmacology, College of Pharmacy, Seoul National University, Seoul, Korea.
5Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea; Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
6Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.

*Corresponding author.

Abstract

Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.

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