상위피인용논문
- 조회625
Jihyun Kim1 • Hyunhee Kim1 • Heewon Roh1 • Youngjoo Kwon1*
1 Ewha Institute for Global Pharmacy Leadership, College of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea
Jihyun Kim, Hyunhee Kim, and Heewon Roh are equal contributors.
*Corresponding author.
Abstract
In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia is a state in which too much homocysteine is present in the body. The main cause of hyperhomocysteinemia is a dysfunction of enzymes and cofactors associated with the process of homocysteine biosynthesis. Other causes include excessive methionine intake, certain diseases and side effects of some drugs. Hyperhomocysteinemia is a trigger for many diseases, such as atherosclerosis, congestive heart failure, age-related macular degeneration, Alzheimer’s disease and hearing loss. There are many studies showing a positive relationship between homocysteine level and various symptoms. We speculate that a high level of homocysteine can be the sole reason or an aggravating factor in numerous diseases for which causal links are not fully understood.
논문정보
- Review Paper
- 2018년 03월 (BRIC 등록일 2022-09-06)
- 국내 연구진
- 의약학 > 약학
- 120회 이상 인용된 논문
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