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상위피인용논문

조회746

원광대학교

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Clin. Exper. Med., Published 11 April 2014 | https://doi.org/10.1007/s10238-013-0271-4 PBMC and exosome-derived Hotair is a critical regulator and potent marker for rheumatoid arthritis

Song, J.^a, Kim, D.^a, Han, J.^a, Kim, Y.^a, Lee, M.^b*, Jin, E.-J.^a*

^aDepartment of Biological Sciences, College of Natural Sciences, Wonkwang University, Iksan, Chunbuk 570-749, South Korea
^bDivision Rheumatology, Department of Internal Medicine, School of Medicine, Wonkwang University, Iksan, 570-749, South Korea

^*Corresponding author

Abstract

Despite growing importance of long non-coding RNAs (lncRNAs) in normal physiological and disease conditions, our knowledge of RA-related lncRNAs remains limited. Therefore, we aimed to identify lncRNA signatures that have prognostic values in RA. There was a notably high expression level of Hotair in blood mononuclear cells and serum exosome of rheumatoid arthritis (RA) patients, leading the migration of active macrophage. In contrast, markedly lower level of Hotair was detected in differentiated osteoclasts and rheumatoid synoviocytes and enforced expression of Hotair led to significantly decreased levels of MMP-2 and MMP-13. This exploratory study provides novel empirical evidence that Hotair could be one of potential biomarkers for diagnosing RA.

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