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Respirology, Volume14, Issue1 January 2009 Pages 27-38 | https://doi.org/10.1111/j.1440-1843.2008.01447.x Impact of oxidative stress on lung diseases

HEE SUN PARK,¹SO RI KIM²AND YONG CHUL LEE²

¹Department of Internal Medicine, Chungnam National University Medical School, Daejeon, and ²Departmentof Internal Medicine, Airway Remodeling Laboratory, Chonbuk National University Medical School, Jeonju, Korea

Correspondence: Yong Chul Lee

Abstract

Reactive oxygen species (ROS) are products of normal cellular metabolism and are known to act as second messengers. Under physiological conditions, ROS participate in maintenance of cellular ‘redox homeostasis’ in order to protect cells against oxidative stress through various redox‐regulatory mechanisms. Overproduction of ROS, most frequently due to excessive stimulation of either reduced nicotinamide adenine dinucleotide phosphate by cytokines or the mitochondrial electron transport chain and xanthine oxidase, results in oxidative stress. Oxidative stress is a deleterious process that leads to lung damage and consequently to various disease states. Knowledge of the mechanisms of ROS regulation could lead to the pharmacological manipulation of antioxidants in lung inflammation and injury.

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