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Mol. Cells, 2018 Feb 28; 41(2): 83–92. | https://doi.org/10.14348/molcells.2018.2242 The Role of Hippo Pathway in Cancer Stem Cell Biology

Jae Hyung Park, Ji Eun Shin, and Hyun Woo Park^*

Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea

^*Correspondence

Abstract

The biological significance and deregulation of the Hippo pathway during organ growth and tumorigenesis have received a surge of interest in the past decade. The Hippo pathway core kinases, MST1/2 and LATS1/2, are tumor suppressors that inhibit the oncogenic nuclear function of YAP/TAZ and TEAD. In addition to earlier studies that highlight the role of Hippo pathway in organ size control, cell proliferation, and tumor development, recent evidence demonstrates its critical role in cancer stem cell biology, including EMT, drug resistance, and self-renewal. Here we provide a brief overview of the regulatory mechanisms of the Hippo pathway, its role in cancer stem cell biology, and promising therapeutic interventions.

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