상위피인용논문
울산의대, 서울아산병원
Juneyoung Lee, PhD,1,* Kyung Won Kim, MD, PhD,2,* Sang Hyun Choi, MD,2 Jimi Huh, MD,2 and Seong Ho Park, MD, PhD2
1Department of Biostatistics, Korea University College of Medicine, Seoul 02841, Korea.
2Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Corresponding author: Seong Ho Park, MD, PhD
*Juneyoung Lee and Kyung Won Kim contributed equally to this work.
Abstract
Meta-analysis of diagnostic test accuracy studies differs from the usual meta-analysis of therapeutic/interventional studies in that, it is required to simultaneously analyze a pair of two outcome measures such as sensitivity and specificity, instead of a single outcome. Since sensitivity and specificity are generally inversely correlated and could be affected by a threshold effect, more sophisticated statistical methods are required for the meta-analysis of diagnostic test accuracy. Hierarchical models including the bivariate model and the hierarchical summary receiver operating characteristic model are increasingly being accepted as standard methods for meta-analysis of diagnostic test accuracy studies. We provide a conceptual review of statistical methods currently used and recommended for meta-analysis of diagnostic test accuracy studies. This article could serve as a methodological reference for those who perform systematic review and meta-analysis of diagnostic test accuracy studies.
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