Guang Hui Gao (성균관대학교) | 상위피인용논문 > 한빛사

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Guang Hui GaoGuang Hui Gao

성균관대학교

J. Control. Release, Volume 169, Issue 3, 10 August 2013, Pages 180-184 | https://doi.org/10.1016/j.jconrel.2012.11.012 Environmental pH-sensitive polymeric micelles for cancer diagnosis and targeted therapy

Guang Hui Gao¹, Yi Li, Doo Sung Lee^*

Department of Polymer Science and Engineering, Theranostic Macromolecules Research Center, Sungkyunkwan University, Suwon, Republic of Korea

¹Dr. Guang Hui Gao is presently a Professor in the Engineering Research Center of Synthetic Resin and Special Fiber, Ministry of Education, Changchun University of Technology, China.

^*Corresponding author

Abstract

The delivery and control over the release of hydrophobic imaging markers for cancer diagnosis or pharmaceutical agents for targeted therapy are of considerable interest. Nano-sized pH-sensitive polymeric micelles that rely on the enhanced permeability and retention (EPR) of vasculature and the low-pH microenvironment in cancer tissue are emerging as stimuli-responsive targeted therapies that can simultaneously release diagnostic and therapeutic agents into a cancerous region. This review focuses on the developments of pH-sensitive polymeric micelles and their biomedical applications in cancer diagnosis and targeted therapy.

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