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Cancer, Volume 110, Issue 12, pages 2716-2725, 15 December 2007 | DOI: 10.1002/cncr.23094 Quality of life and sexual problems in disease-free survivors of cervical cancer compared with the general population

Sang Yoon Park MD, PhD^1,†, Duk-Soo Bae MD, PhD^2,†, Joo Hyun Nam MD, PhD³, Chong Taik Park MD, PhD⁴, Chi-Heum Cho MD, PhD⁵, Jong Min Lee MD, PhD⁶, Myung Kyung Lee RN, MPH⁷, Soo Hyun Kim RN, MS⁷, Sang Min Park MD, PhD⁷ andYoung Ho Yun MD, PhD^7,‡,*¹Center for Uterine Cancer, National Cancer Center, Goyang, Gyeonggi, Korea

²Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

³Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

⁴Department of Obstetrics and Gynecology, Kangnam Cha Hospital, College of Medicine, Pochon Cha University, Seoul, Korea

⁵Department of Obstetrics and Gynecology, School of Medicine, Keimyung University, Daegu, Korea

⁶Department of Obstetrics and Gynecology, East-West Neo Medical Center, Kyung Hee University, Seoul, Korea

⁷Quality of Cancer Care Branch, Research Institute for National Cancer Control and Evaluation, National Cancer Center, Goyang, Gyeonggi, Korea

^†Sang Yoon Park and Duk-Soo Bae contributed equally to this work as first authors.

^*Corresponding author

Abstract

BACKGROUND.

The purpose of this study was to identify problems related to long-term quality of life (QOL) and sexual function in cervical cancer survivors.

METHODS.

The authors enrolled 860 women (median time since diagnosis, 5.86 years) with a history of cervical cancer (stage I to IVa) who had been treated at any of 6 hospitals from 1983 through 2004 and 494 control subjects selected randomly from a representative sample of Korean women. Subjects filled out a questionnaire that included the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, its Cervical Cancer Module, and additional sexual function items.

RESULTS.

Cervical cancer survivors had clinically significant worse problems with social functioning, constipation, diarrhea, and difficulties with their finances than controls (P < .01). Survivors also reported more severe lymphedema and menopausal symptoms and worse body image, sexual and/or vaginal functioning, and sexual worry (P < .01). Anxiety about sexual performance was more problematic in survivors than in controls (P < .01), as was dyspareunia for women who received radiotherapy (P < .01).

CONCLUSIONS.

These findings can increase the awareness of healthcare providers to the potential need for counseling and other interventions among women who have been successfully treated for cervical cancer and could help them improve their impaired QOL. Cancer 2007. ⓒ 2007 American Cancer Society.

Keywords : quality of life;sexual problems;cervical cancer;disease-free survivors

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