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POSTECH, 기초과학연구원

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ACS Nano, Publication Date (Web): March 08, 2016 | DOI: 10.1021/acsnano.5b07483 Light-Induced Acid Generation on a Gatekeeper for Smart Nitric Oxide Delivery

Hyung Woo Choi^†∥, Jihoon Kim^†∥, Jinhwan Kim^‡, Yonghwi Kim^†, Hyun Beom Song^§, Jeong Hun Kim^§, Kimoon Kim^†‡, and Won Jong Kim^*†‡

^†Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea

^‡Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea

^§Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Republic of Korea

^∥Author Contributions
H. W. Choi and J. Kim contributed equally to this work.

^*Corresponding Author

Abstract

We report herein the design of a light-responsive gatekeeper for smart nitric oxide (NO) delivery. The gatekeeper is composed of a pH-jump reagent as an intermediary of stimulus and a calcium phosphate (CaP) coating as a shielding layer for NO release. The light irradiation and subsequent acid generation are used as triggers for uncapping the gatekeeper and releasing NO. The acids generated from a light-activated pH-jump agent loaded in the mesoporous nanoparticles accelerated the degradation of the CaP-coating layers on the nanoparticles, facilitating the light-responsive NO release from diazeniumdiolate by exposing a NO donor to physiological conditions. Using the combination of the pH-jump reagent and CaP coating, we successfully developed a light-responsive gatekeeper system for spatiotemporal-controlled NO delivery.

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