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연세대학교 의과대학 용인세브란스병원
Eur. J. Neurol., Oct 2023, 30 (10) | https://doi.org/10.1111/ene.15999
Association between choroid plexus volume and cognition in Parkinson disease
Seong Ho Jeong 1 2, Hyun-Jae Jeong 3, Mun Kyung Sunwoo 4, Sung Soo Ahn 5, Seung-Koo Lee 5, Phil Hyu Lee 2, Yun Joong Kim 2 6 7, Young H Sohn 2, Chae Jung Park 8 *, Seok Jong Chung 2 6 7 *
1Department of Neurology, Inje University Sanggye Paik Hospital, Seoul, Korea.
2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
3Research Institute of Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea.
4Department of Neurology, Bundang Jesaeng General Hospital, Seongnam-si, Korea.
5Department of Radiology, Severance Hospital, Research Institute of Radiological Science and Centre for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea.
6Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea.
7YONSEI BEYOND LAB, Yongin, Korea.
8Department of Radiology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea.
2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
3Research Institute of Center for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea.
4Department of Neurology, Bundang Jesaeng General Hospital, Seongnam-si, Korea.
5Department of Radiology, Severance Hospital, Research Institute of Radiological Science and Centre for Clinical Imaging Data Science, Yonsei University College of Medicine, Seoul, Korea.
6Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea.
7YONSEI BEYOND LAB, Yongin, Korea.
8Department of Radiology, Yongin Severance Hospital, Yonsei University Health System, Yongin, Korea.
*Corresponding authors: correspondence to Chae Jung Park or Seok Jong Chung
Abstract
Background and purpose
The choroid plexus (CP) clears harmful metabolites from the central nervous system as part of the glymphatic system. We investigated the association of CP volume (CPV) with baseline and longitudinal cognitive decline in patients with Parkinson disease (PD).
Methods
We retrospectively reviewed the medical records of 240 patients with newly diagnosed PD who had undergone detailed neuropsychological tests and high-resolution T1-weighted structural magnetic resonance imaging during the initial assessment. The CPV of each patient was automatically segmented, and the intracranial volume ratio was used in subsequent analyses. The relationship between CPV and baseline composite scores of each cognitive domain was assessed using multivariate linear regression analyses. A Cox proportional hazards model was used to compare the risk of dementia conversion with CPV.
Results
CPV negatively correlated with composite scores of the frontal/executive function domain (β = −0.375, p = 0.002) after adjusting for age, sex, years of education, and parkinsonian symptom duration. The Cox regression model revealed that a larger CPV was associated with a higher risk of dementia conversion (hazard ratio [HR] = 1.509, p = 0.038), which was no longer significant after adjusting for the composite scores of the frontal/executive function domain. A mediation analysis demonstrated that the effect of CPV on the risk of dementia conversion was completely mediated by frontal/executive function (direct effect: HR = 1.203, p = 0.396; indirect effect: HR = 1.400, p = 0.015).
Conclusions
Baseline CPV is associated with baseline frontal/executive function, which subsequently influences dementia conversion risk in patients with PD.
The choroid plexus (CP) clears harmful metabolites from the central nervous system as part of the glymphatic system. We investigated the association of CP volume (CPV) with baseline and longitudinal cognitive decline in patients with Parkinson disease (PD).
Methods
We retrospectively reviewed the medical records of 240 patients with newly diagnosed PD who had undergone detailed neuropsychological tests and high-resolution T1-weighted structural magnetic resonance imaging during the initial assessment. The CPV of each patient was automatically segmented, and the intracranial volume ratio was used in subsequent analyses. The relationship between CPV and baseline composite scores of each cognitive domain was assessed using multivariate linear regression analyses. A Cox proportional hazards model was used to compare the risk of dementia conversion with CPV.
Results
CPV negatively correlated with composite scores of the frontal/executive function domain (β = −0.375, p = 0.002) after adjusting for age, sex, years of education, and parkinsonian symptom duration. The Cox regression model revealed that a larger CPV was associated with a higher risk of dementia conversion (hazard ratio [HR] = 1.509, p = 0.038), which was no longer significant after adjusting for the composite scores of the frontal/executive function domain. A mediation analysis demonstrated that the effect of CPV on the risk of dementia conversion was completely mediated by frontal/executive function (direct effect: HR = 1.203, p = 0.396; indirect effect: HR = 1.400, p = 0.015).
Conclusions
Baseline CPV is associated with baseline frontal/executive function, which subsequently influences dementia conversion risk in patients with PD.
논문정보
- Research article
- 2023년 10월 (BRIC 등록일 2026-05-11)
- 국내 연구진
- 의약학 > 신경의학
- 60회 이상 인용된 논문
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