하기태 (부산대학교 한의과학과) | 상위피인용논문 > 한빛사

상위피인용논문

조회22

부산대학교 한의과학과

CV File

Front. Pharmacol., 2025, 16 1615338 | https://doi.org/10.3389/fphar.2025.1615338 Impact of extraction techniques on phytochemical composition and bioactivity of natural product mixtures

Shicai Sun ¹, Ying Yu ¹, Yunju Jo ², Jung Ho Han ³, Yingqi Xue ², Minkyoung Cho ⁴, Sung-Jin Bae ⁵, Dongryeol Ryu ², Wonyoung Park ^2,6,7,*, Ki-Tae Ha ^6,7,*, Shiwei Zhuang^1,*

¹Department of Surgery, Changchun University of Chinese Medicine, Changchun, China
²Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
³Korean Medicine Application Center, Korea Institute of Oriental Medicine, Daegu, Republic of Korea
⁴Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju, Republic of Korea
⁵Department of Molecular Biology and Immunology, Kosin University College of Medicine, Busan, Republic of Korea
⁶Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea
⁷Research Institute for Korean Medicine, Pusan National University, Yangsan, Republic of Korea

^*Corresponding authors: correspondence to Wonyoung Park, Ki-Tae Ha or Shiwei Zhuang

Abstract

Extraction methods critically influence the phytochemical profile and bioactivity of natural product mixtures, affecting their efficacy as therapeutic agents. This review assesses the impact of various extraction techniques-such as solvent-based extraction, ultrasound-assisted extraction, and enzymatic extraction-on the composition of bioactive compounds in plant extracts. We discuss how extraction parameters modify the bioactivity profiles, influencing their application in pharmaceutics and nutrition. This review critically analyzes these techniques with a special focus on integrated (hybrid) strategies, revealing that while advanced methods like ultrasound-assisted extraction and microwave-assisted extraction offer improved efficiency, the greatest potential lies in the synergistic combination of methods to maximize yield and preserve bioactivity. The insights gathered here aim to guide researchers in developing optimal and sustainable extraction protocols for therapeutic applications.

논문정보