한빛사 인터뷰
1. Can you please briefly summarize the paper?
Biodegradable metals, notably magnesium alloys, are emerging as promising materials for cranial bone reconstruction due to their biodegradability. The biodegradable properties and exceptional mechanical strength of magnesium alloys make them superb materials for cranial bone reconstruction procedures. Their degradable nature allows for easy MRI diagnostics in cases of subsequent complications within the brain post-surgery. Despite their widespread application as biodegradable implants, the rapid degradation rate of magnesium alloys poses a significant obstacle to their commercial viability. Ideally, the degradation timeline of these implants should align with the tissue's recovery duration, which, for bone, is approximately 3 months. Therefore, magnesium alloys employed in bone regeneration should retain their mechanical integrity for a minimum of this duration.
This research deals with challange to control the high degradable rate of Mg alloy implants for their biomedical application specially bone regeneration. For this purpose Mg alloy mesh samples were coated with Zn-d/Ca-P and Zn-d/Ca-P/P and subjected to comprehensive analytical characterization, in vitro biocompatibility, osteogenic, and angiogenesis evaluations, alongside in vivo compatibility, and bone regeneration assessments through rat calvarial model implantation. Our findings reveal that both Zn-d/Ca-P and Zn-d/Ca-P/P variants can significantly contribute to bone regeneration, with the Zn-d/Ca-P /P coating notably decreasing magnesium alloy degradation. Additionally, in vivo results confirm the samples’ enhanced angiogenic and osteogenic capabilities. A molecular simulation has been utilized to predict the Zn ions’ affinity for MMPs, integral to angiogenesis regulation, thus supporting the potential of Zn-d/Ca-P and Zn-d/Ca-P/P in revolutionizing cranial bone regeneration implant usage and broadening the scope within the biomedical device sector.
2. Can you please tell us the main difficulties you had in the laboratory work and how you overcame them?
Throughout my research journey, I’ve encountered several challenges in the laboratory, each of which has taught me valuable lessons. One of the main difficulties I faced was working on interdisciplinary projects that required me to integrate knowledge from diverse fields, such as chemistry, biology, and material science. At times, I felt stretched outside my expertise, especially when learning advanced molecular techniques or adapting new analytical methods. To overcome this, I took a proactive approach by studying relevant literature, attending workshops, and seeking guidance from peers and mentors who specialized in those areas. This not only helped me develop new skills but also strengthened my ability to collaborate effectively in an interdisciplinary environment.
Working in a fast-paced research environment also meant staying up-to-date with rapidly evolving technologies. Initially, it was daunting to keep up, but I overcame this by dedicating time to self-study, participating in collaborative projects, and consistently updating my skill set to align with the latest advancements.
These experiences taught me resilience, adaptability, and the importance of teamwork. They reaffirmed my belief that challenges in research are opportunities for growth, and every problem solved contributes not only to personal development but also to the advancement of science as a whole.
3. Please introduce your laboratory, university or organization to bio-researchers in Korea.
The Institute of Tissue Regeneration (ITR) is a multidisciplinary research group dedicated to advancing biomaterials research and development. The group adopts an interdisciplinary approach, bringing together experts from various fields to solve complex scientific problems. ITR's research focuses on the design, development, characterization, and evaluation of biomaterials, as well as their biocompatibility and behavior in biological environments.
The group is at the forefront of fusion technology, integrating nano-technology and bio-technology (NT-BT) to develop innovative biomedical systems. These include bone substitutes, artificial bones, blood vessels, kidneys, and other tissue and organ regeneration solutions. Using bioceramics and biopolymers, biomedical devices are designed, optimized, and characterized, with systematic in vitro and in vivo investigations to ensure their effectiveness.
Currently, the lab is exploring organ regeneration through decellularization and recellularization techniques. By generating extracellular matrices (ECMs) both in vitro and in vivo, the group is working to create improved biomaterials for applications like bone regeneration. This interdisciplinary and innovative approach makes ITR a leader in biomaterials and regenerative medicine research.
4. Please tell us your experiences and your thoughts related to research activities abroad.
Conducting research abroad has been one of the most enriching and eye-opening experiences of my career. It has given me the opportunity to work in diverse, interdisciplinary environments where collaboration and innovation are at the forefront. My research experiences abroad have taught me the importance of flexibility and adaptability, as I was often exposed to new methodologies and advanced technologies that required me to step out of my comfort zone.
One of the most valuable lessons I’ve learned is that science transcends borders?ideas flourish when people from different backgrounds come together with a shared purpose. For instance, while working on this project, I collaborated with scientists from various fields, such as material science, molecular biology, and clinical medicine. These collaborations not only enhanced the quality of our research but also deepened my understanding of how interdisciplinary efforts can address complex global challenges.
Researching abroad also pushed me to stay at the forefront of emerging trends in science and technology. Whether it was adopting cutting-edge analytical techniques or exploring new areas like nanostructures for regenerative medicine, the exposure was invaluable. While the journey wasn’t without challenges?adapting to new cultures, navigating language barriers, and balancing high expectations?I found that these obstacles ultimately strengthened my problem-solving skills and resilience.
Overall, my time researching abroad has shaped my perspective as a scientist, emphasizing the importance of continuous learning, collaboration, and perseverance. I am deeply grateful for these opportunities and remain committed to contributing to the global scientific community by sharing knowledge and fostering meaningful collaborations.
5. Can you provide some advice for younger scientists who have plans to study abroad?
Studying abroad has been a transformative experience for me, and it’s one that requires not just determination but a constant willingness to learn and adapt. For younger scientists planning to take this step, my biggest advice is to embrace interdisciplinary studies wholeheartedly?it’s an area where innovation thrives, but it demands a commitment to continuously acquiring new knowledge and skills. I’ve found that staying open to learning beyond my core expertise has allowed me to make meaningful contributions to diverse projects. Don’t hesitate to seek help and advice from your peers?collaboration is one of the most valuable aspects of working in an international research environment. At the same time, the world of science is fast-paced and ever-changing, so it’s crucial to stay adaptable and keep up with emerging trends and technologies. Challenges will inevitably arise, whether it’s adjusting to a new culture or navigating the complexities of research, but perseverance will always lead you forward. Never give up, and remember that every obstacle you overcome is shaping you into a stronger, more innovative scientist.
6. Future plan?
My future plans are focused on continuing to push the boundaries of interdisciplinary research in the field of biomedical sciences. I aim to further explore the convergence of chemistry, biotechnology, and nanotechnology to develop innovative solutions for tissue and organ regeneration, as well as advanced molecular diagnostics. I plan to contribute to the development of more efficient biomaterials and systems that can improve human health, with a specific focus on personalized and regenerative medicine.
7. Do you have anything else that you would like to tell Korean scientists and students?
As someone who has had the privilege to work at the intersection of chemistry, biotechnology, and biomedical sciences, I deeply admire the innovative spirit of Korean scientists and students. South Korea has consistently been at the forefront of groundbreaking research, and I believe this progress is fueled by a strong culture of collaboration and perseverance.
To students, I’d like to say: never underestimate the power of curiosity. The path of science is challenging but immensely rewarding, especially when we can contribute to solving real-world problems. Embrace interdisciplinary research?it’s often at these intersections that the most transformative discoveries are made.
I am honored to contribute to this dynamic research community, and I hope my journey can inspire others to pursue their passion for science, work across disciplines, and dream big for the future of humanity.
#Biomaterials
# Tissue regeneration
# Bio-nanotechnology
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