1. Can you please briefly summarize the paper? 

The identification and avoidance of harmful taste stimuli play a crucial role in the maintenance of homeostasis and the survival of various species in the animal kingdom. One such compound that has garnered our attention i.e. cantharidin, a monoterpenoid believed to have aphrodisiac properties. It is produced by numerous blister beetle species, with the Spanish fly, Lytta vesicatoria, being a prominent source. While the advantageous functions of cantharidin have been studied, its taste analysis and toxic effects on animals remain relatively unexplored. In this study, we focused on Drosophila melanogaster to delve into the taste properties of cantharidin and its potential harm to internal organs. Our research revealed that cantharidin activates bitter taste receptors. Specifically, certain ionotropic receptors (IR7g, IR51b, and IR94f) found in labellar bitter-sensing neurons, along with co-receptors IR25a and IR76b, were identified as responsible for detecting cantharidin. Through ectopic expression analysis we found that IR7g and IR51b genes alone are sufficient for the perception of cantharidin. Furthermore, our findings highlight the deleterious effects of cantharidin on survival and visceral integrities, highlighting its hazardous nature. This study contributes to a better understanding of how organisms perceive and respond to cantharidin and analyzes the toxic properties of cantharidin.

2. Can you please tell us the main difficulties you had in the laboratory work and how you overcame them?

Rather than the difficulties, I thoroughly enjoyed my laboratory work. However, one notable challenge I encountered was in the imaging phase. While I was passionate about the overall research, the imaging aspect presented a learning curve for me. Given that it was a relatively new experience, I had to invest extra effort to become proficient in the imaging techniques required for the study. I am glad that through persistent hard work and a proactive approach to skill development, I eventually became adept at the imaging procedures and hence this dedication not only helped me overcome the difficulties, but also contributed to the successful completion of the research project. The satisfaction of overcoming these specific challenges added a valuable layer to my overall research experience.

3. Please introduce your laboratory, university or organization to bio-researchers in Korea.

Our research laboratory name is Intelligence genetics laboratory which is affiliated with the Department of Bio & Fermentation Convergence Technology at Kookmin University in Seoul. It is dedicated to investigating the complex world of molecular genetics. At our laboratory, we study a wide range of topics, including taste sensation, cellular neuroscience of temperature sensation, circadian rhythm, sleep regulation, and metabolism. Our team is dedicated to understanding the complexities of chemo sensation, circadian rhythm, and animal metabolism by employing a variety of advanced techniques such as behavioral assays, electrophysiology, immunohistochemistry, DAM system, metabolic measurement assays, the DrosoX technique, and other molecular methodologies. The fundamental purpose of our study is to understand the precise mechanisms driving these physiological processes, therefore providing useful insights to the scientific community.

4. Please tell us your experiences and your thoughts related to research activities abroad.

Participating in research activities overseas has not only broadened my scientific horizons, but also given me a worldwide perspective on the challenges and developments in my profession. It has been an amazing experience, allowing me to grasp the variety of research techniques and procedures used in different countries. My involvement in the international research activities has helped shape my scientific career and I am excited about the future international collaborations because I believe in the ability of a global scientific community to handle complicated challenges and promote innovation in the field of research.

5. Can you provide some advice for younger scientists who have plans to study abroad?

Based on my personal experience, I would advise ambitious young scientists seeking to study overseas to stay persistent and resilient. To succeed in studying abroad, young scientists should research their destination thoroughly, build a strong support network, and be adaptable and open-minded. Studying abroad may provide unique obstacles, but persistence and resilience are essential for conquering them. Maintain your commitment to your research objectives and remember that overcoming challenges is an essential part of the scientific process. They should be aware of the research landscape, develop a strong support network, and be open to new methodologies and cultural norms. Embracing the opportunities and remaining curious can help them make the most of this transformative period in their scientific career. This holistic experience can shape personal and professional growth.

6. Future plan?

My future plan concentrates upon a strong desire to advance scientific knowledge, particularly in the fields of neurological and disease-related studies. Building on my present study focusing on taste perception in Drosophila, I am motivated to extend my research to higher species, notably diving into the intricacies of neurological illnesses relevant to humans. The possibility of unravelling the complexities of the brain and its functioning, as well as researching disorders with serious consequences for human health, drives me tremendously. To achieve these goals, I intend to pursue advanced studies in a subject where I may concentrate in neurobiology or a similar discipline. Finally, my goal is to contribute to the scientific community as a motivated and effective researcher. I hope to develop research that not only broadens our understanding of neurology, but also has practical implications in dealing with the problems provided by neurological illnesses. Overall, my long-term goal is to immerse myself in cutting-edge research, contribute to advances in neurobiology, and eventually emerge as a scientist devoted to enhancing our understanding of the brain and developing treatments for neurological illnesses.

7. Do you have anything else that you would like to tell Korean scientists and students?

As a researcher dedicated to advancing knowledge in the scientific field, I would like to express my appreciation and respect for the Korean scientific community and students. Collaboration and exchange of knowledge are critical to scientific development, and I am eager to meet with Korean researchers. I also urge students to pursue their academic interests enthusiastically, seek monitoring, and participate in multidisciplinary studies. The global scientific community flourishes when we exchange ideas and collaborate, and I’m excited about the possible opportunity to contribute to and learn from Korea’s research environment.