한빛사 인터뷰
- 등록2023-11-01
- 조회452
1. Can you please briefly summarize the paper?
In this study, we prepared a coenzyme A (CoA-SH)-responsive electronic hydrogel sensor that can relieve osteoarthritis based on carbonized polydopamine-integrated disulfide bonds-contained polymer dots (cPDA@PD hydrogel). The detection principle is based on the redox reaction between the CoA-SH with the disulfide bond of the system, thus controlling the detachment of the loaded carbonized polydopamine (cPDA) inside the hydrogel. Additionally, this cPDA@PD hydrogel sensor demonstrated a method of detection that relied on the integrated change in optical, electrical, and mechanical properties by the CoA-SH of OA disease.
2. Can you please tell us the main difficulties you had in the laboratory work and how you overcame them?
The main obstacle for this project is the optimization steps. We can state that if the ratio of material in the preparation step was altered, the conductivity is dramatically changed. To overcome it, the only way is just to keep trying.
3. Please introduce your laboratory, university or organization to bio-researchers in Korea.
I have joined the Functional Biomaterials Lab (FBL) of the Department of Chemical and Biological Engineering at the Korea National University of Transportation. Here are some of the highlighted focuses of our lab stated as follow:
- Preparation of drug delivery system with dual functionality as therapeutic material and for sensing.
- Development of carbon/polymer dots for theragnostic and sensing applications via acid-assisted
and hydrothermal carbonization based on natural and synthetic polymers.
- Fabrication of conductive hydrogel for the detection of diseases such as osteoarthritis, fatty liver
disease, and cancer.
- Design of hydrogel for artificial skin and actuator.
4. Please tell us your experiences and your thoughts related to research activities abroad.
I always believed that knowledge is universal, but the approach is different. Some part that I studied in my previous institute is quite different from the thing that I got in South Korea, but once you know the principle, it is literally the same. An example of this is the interaction between metal-ligand interaction. Before coming to Korea, I just knew that the type of interaction is a coordination bond (complex), but once I came here, most people said it was an ionic complex. I realized it was similar in particular once I saw the mechanism and principle of the design. Even with so many different, I am really glad that I came to South Korea. I learned a lot of things here that I probably couldn’t obtain at another place in term of research and study.
5. Can you provide some advice for younger scientists who have plans to study abroad?
“If there is a will, there is a way” is one of the old proverbs that I kept in mind even before I arrived in South Korea. I always think that failure is just a lesson until you get the best place, position, and path. Thus, never give up and keep trying.
No matter how hard a situation is, just keep moving forward. That is how ancient, medieval, and previous generation of scientist pass through their wisdom to all of us today.
6. Future plan?
Now, my position is as a research professor, but I plan to become a full-pledge professor (academic professor). For the initial step, I will find a tenure-track assistant professor position. For research, I plan to establish my knowledge in the preparation and application of hydrogel while enhancing my skills in biosensing and bioactuating.
7. Do you have anything else that you would like to tell Korean scientists and students?
Similar with volleyball, research is not a one-man play, so we need advice and collaborate with each other. I will also address this part to me and another foreigner scientist.
#hydrogel
# biosensor
# osteoarthritis
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