한빛사 인터뷰
- 등록2023-10-19
- 조회491
1. Can you please briefly summarize the paper?
The paper describes a unique pattern of genomic imprinting which is essential for normal mammalian development. We identified a differentially methylated region (DMR) in the KBTBD6 locus using porcine parthenogenetic embryos. This differential DNA methylation was conserved in livestock species. The corresponding monoallelic expression of the KBTBD6 gene further indicated that this gene is a novel livestock-specific imprinted gene. Our comparative epigenetics study revealed species-specific evolution of genomic imprinting at the KBTBD6 locus.
2. Can you please tell us the main difficulties you had in the laboratory work and how you overcame them?
There were difficulties on completing the research on time. We discovered a previously unknown imprinted gene independently but, while we were preparing our manuscript, we noticed that there was another research team that reported about this gene. Therefore, we had to conduct additional work to provide more detailed mechanistic and functional insights regarding this gene.
3. Please introduce your laboratory, university or organization to bio-researchers in Korea.
We belong to a functional genomics lab in the Department of Animal Sciences at The Ohio State University. Using various animal models including agriculturally important livestock and translational models to humans, we investigate developmental, nutritional, and tissue-specific regulation of gene expression and the functional consequences. Our combined approaches of genetics/genomics and epigenetics/epigenomics advance our understanding of the genetic architecture of a whole organism.
4. Please tell us your experiences and your thoughts related to research activities abroad.
Doing research abroad provides opportunities to explore a variety of study areas, but eventually, one should focus on developing specialties through independent thinking.
5. Can you provide some advice for younger scientists who have plans to study abroad?
My advice to young scientists who plan to study abroad is to be open-minded learners. In this context, you will need to understand that your colleagues have different cultural and educational backgrounds.
6. Future plan?
Future plans include identifying a complete landscape of genomic imprinting in livestock species, experimental animals, and humans and developing comprehensive analytical approaches to validate our findings.
7. Do you have anything else that you would like to tell Korean scientists and students?
The areas of sequencing technologies including whole genome sequencing, whole genome bisulfite sequencing, RNA-seq, ChIP-seq, and Hi-C, along with genome editing, have been revolutionizing the field of life sciences and will continue to do so. Conceptualizing research topics while being familiar with these appropriate technological innovations will strengthen future research plans.
#Genomic imprinting
# Epigenetics
# Livestock
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