![3-Deazaneplanocin A 히스톤 메틸전이효소 억제제 [ 1029595 ] - BioGems Small Molecules](/app/board/attach/image/thumb_1327328_1751769185000.do)
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3-Deazaneplanocin A 히스톤 메틸전이효소 억제제 [ 1029595 ] - BioGems Small Molecules
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3-Deazaneplanocin A
3-Deazaneplanocin A는 histone 3의 lysine 27의 메틸화를 억제하는 epigenetic modifier 입니다. 이 작용의 메커니즘은 lysine methyltransferases inhibitor, 특히 EZH2의 억제입니다.
암세포의 세포사멸을 유도하며, 화학적으로 유도된 만능줄기세포(CiPSCs)의 생성에 유용한 것으로 보고되고 있습니다.
| SIZE | PRICE (부가세별도) | 판매번호 |
|---|---|---|
| 1mg | $180.00 | 1029595-1mg |
| 5mg | $495.00 | 1029595-5mg |
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- Product should be kept at -20°C. Sterilize with 0.22 µm filter before use.
Catalog Number : 1029595
ADDITIONAL INFORMATION
Applications: | FA |
Synonyms: | DZNep, NSC 617989 |
Formulation: | Crystalline solid |
Chemical Name: | (1S,2R,5R)-5-(4-aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol |
Molecular Formula: | C12H14N4O3 |
Molecular Weight: | 262.3 |
CAS Number | 102052-95-9 |
Purity: | ≥97% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Fiskus, W., Wang, Y., Sreekumar, A., Buckley, K. M., Shi, H., Jillella, A., … & Bhalla, K. N. (2009). Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood, 114(13), 2733-2743. Glazer, R. I., Hartman, K. D., Knode, M. C., Richard, M. M., Chiang, P. K., Tseng, C. K., & Marquez, V. E. (1986). 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochemical and biophysical research communications, 135(2), 688-694. Bray, M., Raymond, J. L., Geisbert, T., & Baker, R. O. (2002). 3-Deazaneplanocin A induces massively increased interferon-α production in Ebola virus-infected mice. Antiviral research, 55(1), 151-159. |
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