![SAHA 히스톤 탈아세틸화효소 억제제 [ 1497894 ] - BioGems Small Molecules](/app/board/attach/image/thumb_1327324_1751768970000.do)
연구용제품시약 > Chemical Reagent
SAHA 히스톤 탈아세틸화효소 억제제 [ 1497894 ] - BioGems Small Molecules
바이오젬스코리아 T02-6956-2521 Einfo@bio-gems.co.kr
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카달로그 NO1497894
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생산기업Biogems
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SAHA
SAHA는 class I 및 class II HDACs 을 포함하는 deacetylase에 대해 억제효과를 나타내는 강력한 가역적 pan-histone deacetylase inhibitor 입니다. histone deacetylase 의 활성 부위에 결합하여 아연 이온의 킬레이터로써 작용합니다.
| SIZE | PRICE (부가세별도) | 제품번호 |
|---|---|---|
| 250mg | $60.00 | 1497894-250mg |
| 1g | $195.00 | 1497894-1g |
Catalog Number : 1497894
ADDITIONAL INFORMATION
Applications: | FA |
Synonyms: | Vorinostat, Zolinza, suberoylanilide hydroxamic acid, Suberanilohydroxamic acid |
Formulation: | Crystalline solid |
Chemical Name: | N’-hydroxy-N-phenyloctanediamide |
Molecular Formula: | C14H20N2O3 |
Molecular Weight: | 264.3 |
CAS Number | 149647-78-9 |
Purity: | ≥98% |
Storage Conditions: | Product should be kept at -20°C. |
References: | Duvic, M., Talpur, R., Ni, X., Zhang, C., Hazarika, P., Kelly, C., … & Frankel, S. R. (2007). Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood, 109(1), 31-39. Marks, P. A., & Breslow, R. (2007). Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nature biotechnology, 25(1), 84-90. Shankar, S., Davis, R., Singh, K. P., Kurzrock, R., Ross, D. D., & Srivastava, R. K. (2009). Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice. Molecular cancer therapeutics, 8(6), 1596-1605. |
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