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바이오젬스코리아

  • 등록2026.10.04
  • 조회17
Dibutyryl-cAMP, sodium salt ( cAMP Pathway Activator ) [ 1698950 ]

Dibutyryl-cAMP, sodium salt ( cAMP Pathway Activator ) [ 1698950 ]

본 정보는 "바이오젬스코리아"(으)로 문의 바랍니다.

제품문의 메일보내기바이오젬스코리아 홈페이지 가기BioGems 홈페이지 가기


Dibutyryl-cAMP, sodium salt

Dibutyryl-cAMP는 cAMP-dependent protein kinases activator  및 phosphodiesterase inhibitor 로써 세포투과되는 활성형의, 내인성  cyclic adenosine monophosphate (cAMP)의 유사체입니다. 

Dibutyryl-cAMP는 vascullar smooth muscle cell의 세포자멸사를 유도하고, neurite growth를 유도하는 것으로 보고되었습니다.

 

Catalog Number : 1698950

 
SIZE가격 (부가세별도)제품번호
50mg
$60.00
1698950-50mg
250mg
$250.00
1698950-250mg
  • Download TDS 

  • Preparation & Storage: Soluble in PBS pH 7.2 up to 6.5mM.  (  3.2 mg/mL  ).  Product should be kept at -20°C.  Sterilize with 0.2 um filter before use.    

 

[제품 인용 최신 논문] 

  1. Schuldt BR, Haworth-Staines D, Perez-Arevalo A, Broekaart DWM, Harlock A, Wang L, Bright A, Gallagher G, Rabinowitz G, Goate AM, Raj T, Pereira AC, Blanchard JW. A pericyte-to-myofibroblast transition links APOE4 to cerebrovascular degeneration. Cell. 2026 Sep 24:S0092-8674(26)01069-X. doi: 10.1016/j.cell.2026.08.058. Epub ahead of print. PMID: 42785300.
  2. [ 국내 ] Yeo HC, Bae H, Kim JS, Kang JK, Seok J, Kim YJ, Han YJ, Na YB, Lee SH, Lee J, Gwak SJ, Lee SJ, Cho SG, Kim SW, Cho MC. 3D-printed PCL scaffold coated with chitosan-hyaluronic acid hydrogel loaded with NGF-overexpressing UiPSC-derived neural crest cells restores erectile function via cavernous nerve regeneration. Bioact Mater. 2026 Sep 11;67:842-858. doi: 10.1016/j.bioactmat.2026.07.001. PMID: 42757133; PMCID: PMC13584137.
  3. Mesentier-Louro LA, Goldman C, Gaese S, Buonfiglioli A, Kyriakis D, Harlock A, Ndayisaba A, Sartori ER, Uchitelev A, Fullard JF, Hennigan E, Lee D, Schuldt BR, Rooklin RB, Barra J, Bravo-Cordero JJ, Roussos P, Khurana V, Blanchard JW. Cholesterol dysregulation in APOE4 astrocytes promotes α-synuclein pathology in miBrains. Cell Stem Cell. 2026 Sep 3;33(9):1459-1476.e10. doi: 10.1016/j.stem.2026.08.001. Epub 2026 Aug 24. PMID: 42636814; PMCID: PMC13528747.
  4. [ 국내 ] Chica E, Kwon Y, Jang H, Kim Y, Lee Y, Kim K, Gogos JA, Lee MO, Lee HJ. Millifluidic triMEA organoid platform with stretchable microelectrode arrays for parallel organoid electrophysiology under standardized perfusion. Lab Chip. 2026 Sep 21. doi: 10.1039/d6lc00391e. Epub ahead of print. PMID: 42765769.
  5. Sawada T, Feltrin AS, Wang Y, Araujo B, McCord AE, Giles HH, Han S, Radulescu E, Chen Q, Qamar B, R Barbosa A, Jacomini RS, Lorenzetti APR, Dimitrova V, Kaneva R, Vladimirov V, Kleinman JE, Hyde TM, Weinberger DR, Paquola ACM, Erwin JA. SETD1A regulates psychiatric gene networks involved in genomic stability and synaptic function in rare and sporadic schizophrenia. Nat Commun. 2025 Dec 20;17(1):461. doi: 10.1038/s41467-025-67154-0. PMID: 41422157; PMCID: PMC12800067.
  6. Sarieva K, Kagermeier T, Lysenkov V, Castagnetti F, Yentuer Z, Becker K, Matilainen J, Casadei N, Mayer S. Comparing the impact of sample multiplexing approaches for single-cell RNA-sequencing on downstream analysis using cerebellar organoids. iScience. 2026 Jan 22;29(2):114780. doi: 10.1016/j.isci.2026.114780. PMID: 41743667; PMCID: PMC12930056.
  7. Lian L, Robinson H, Daniels N, Prieto GA, Poplawski GHD, Lopez-Gonzalez R. Aberrant CDK4/6-driven cell-cycle reentry drives neuronal loss and defines a therapeutic target in C9orf72 ALS/FTD. iScience. 2026 Jan 2;29(2):114596. doi: 10.1016/j.isci.2025.114596. PMID: 41623487; PMCID: PMC12856326.
  8. Szewczyk B, Zimyanin V, Japtok J, Held A, Pal A, Großmann D, Glaß H, Jürs AV, Dash BP, Bak M, Naumann M, Hartmann C, Kuksenko O, Günther R, Kao TT, Sameith K, Dahl A, Sterneckert J, Aronica E, Shneider NA, Büttner A, Catanese A, Phatnani H, Kipp M, Wainger BJ, Goswami A, Hermann A. Activation of polo-like kinase 1 correlates with selective motor neuron vulnerability in familial ALS. Cell Rep. 2025 Aug 25:44(9):116113. doi: 10.1016/j.celrep.2025.116113. Epub ahead of print. PMID: 40857153.  [ BioGems 제품이나 Peprotech 으로 표기 ].
  9. D’Ignazio L, Lorenzetti APR, Penney EB, Evans TA, Qamar B, McCord AE, Feltrin AS, Barbosa AR, Sheehan BJ, Araujo B, Giles HH, Wang Y, Sawada T, Zabolocki M, Murcar M, Fernandez-Cerado C, Legarda GP, Sy M, Velasco-Andrada MS, Munoz E, Ang MC, Diesta CCE, Bardy C, Bragg DC, Paquola ACM, Erwin JA. A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration. Cell Rep. 2025 Jul 22;44(7):115812. doi: 10.1016/j.celrep.2025.115812. Epub 2025 Jun 19. PMID: 40540399.
  10. Goldman C, Kareva T, Sarrafha L, Schuldt BR, Sahasrabudhe A, Ahfeldt T, Blanchard JW. Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockout. iScience. 2025 Jun 3;28(7):112816. doi: 10.1016/j.isci.2025.112816. PMID: 40612515; PMCID: PMC12221716.
  11. Lee, Y.; Lee, M.-O. In vitro study: generation of a non-invasive patient-derived neurodegenerative model for spinocerebellar ataxia 6. Organoid 2025, 5, https://doi.org/10.51335/organoid.2025.5.e3.
  12. Yeo H, Kim YJ, Seok J, Kwak Y, Jang SB, Lim NH, Song K, Lee J, Cho MC, Kim SW, Cho SG. Therapeutic potential of NGF-enriched extracellular vesicles in modulating neuroinflammation and enhancing peripheral nerve remyelination. Acta Neuropathol Commun. 2025 May 27;13(1):118. doi: 10.1186/s40478-025-02033-9. PMID: 40420167; PMCID: PMC12107788.
  13. Eubanks E, VanderSleen K, Mody J, Patel N, Sacks B, Farahani MD, Wang J, Elliott J, Jaber N, Akçimen F, Bandres-Ciga S, Helweh F, Liu J, Archakam S, Kimelman R, Sharma B, Socha P, Guntur A, Huang Y, Ramalingam N, Guadagno E, Bartels T, Dettmer U, Mouradian MM, Bahrami AH, Dai W, Baum J, Shi Z, Hardy J, Kara E. Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease. Cell Rep. 2025 May 27;44(5):115636. doi: 10.1016/j.celrep.2025.115636. Epub 2025 May 1. PMID: 40317721.
  14. Kim K, Lee Y, Jung KB, Kim Y, Jang E, Lee MO, Son MY, Lee HJ. Highly Stretchable 3D Microelectrode Array for Noninvasive Functional Evaluation of Cardiac Spheroids and Midbrain Organoids. Adv Mater. 2024 Dec 15:e2412953. doi: 10.1002/adma.202412953. Epub ahead of print. PMID: 39676473.
  15. Kagermeier T, Hauser S, Sarieva K, Laugwitz L, Groeschel S, Janzarik WG, Yentür Z, Becker K, Schöls L, Krägeloh-Mann I, Mayer S. Human organoid model of pontocerebellar hypoplasia 2a recapitulates brain region-specific size differences. Dis Model Mech. 2024 Jul 1;17(7):dmm050740. doi: 10.1242/dmm.050740. Epub 2024 Jul 22. PMID: 39034883; PMCID: PMC11552497.
  16. Hallberg I, Morrell JM, Malaluang P, Johannisson A, Sjunnesson Y, Laskowski D. Sperm quality and in vitro fertilizing ability of boar spermatozoa stored at 4 °C versus conventional storage for 1 week. Front Vet Sci. 2024 Sep 13;11:1444550. doi: 10.3389/fvets.2024.1444550. PMID: 39376925; PMCID: PMC11457738.
  17. Tripathi U, Rosh I, Ben Ezer R, Nayak R, Hussein Y, Choudhary A, Djamus J, Manole A, Houlden H, Gage FH, Stern S. Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations. NPJ Parkinsons Dis. 2024 May 18;10(1):103. doi: 10.1038/s41531-024-00715-0. PMID: 38762512; PMCID: PMC11102563.
  18. Szewczyk B, Günther R, Japtok J, Frech MJ, Naumann M, Lee HO, Hermann A. FUS ALS neurons activate major stress pathways and reduce translation as an early protective mechanism against neurodegeneration. Cell Rep. 2023 Jan 24;42(2):112025.  PMID: 36696267.
  19. Glaß H, Jonitz-Heincke A, Petters J, Lukas J, Bader R, Hermann A. Corrosion Products from Metallic Implants Induce ROS and Cell Death in Human Motoneurons In Vitro. J Funct Biomater. 2023 Jul 25;14(8):392. doi: 10.3390/jfb14080392. PMID: 37623637; PMCID: PMC10455184.
  20. Lee Y, Kang JS, Ham OJ, Son MY, Lee MO. Gut metabolite trimethylamine N-oxide induces aging-associated phenotype of midbrain organoids for the induced pluripotent stem cell-based modeling of late-onset disease. Front Aging Neurosci. 2022 Aug 16;14:925227. doi: 10.3389/fnagi.2022.925227. PMID: 36051303; PMCID: PMC9426463.
  21. Leclercq A, Ranefall P, Sjunnesson YCB, Hallberg I. Occurrence of late-apoptotic symptoms in porcine preimplantation embryos upon exposure of oocytes to perfluoroalkyl substances (PFASs) under in vitro meiotic maturation. PLoS One. 2022 Dec 28;17(12):e0279551. doi: 10.1371/journal.pone.0279551. PMID: 36576940; PMCID: PMC9797085.
  22. Valatkaitė E, Baušytė R, Vitkevičienė A, Ramašauskaitė D, Navakauskienė R. Decidualization Potency and Epigenetic Changes in Human Endometrial Origin Stem Cells During Propagation. Front Cell Dev Biol. 2021 Nov 19;9:765265. doi: 10.3389/fcell.2021.765265. PMID: 34869358; PMCID: PMC8640123.


Catalog Number : 1698950

product image

ADDITIONAL INFORMATION

Applications:
FA
Synonyms:
Compound C, AMPK Inhibitor, BML-275
Formulation:
Crystalline solid
Chemical Name:
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine
Molecular Formula:

C24H25N5O

Molecular Weight:
399.5
CAS Number
866405-64-3
Purity:
≥98%
Storage Conditions:
Product should be kept at -20°C.
References:

Paul, B. Y., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., … & Peterson, R. T. (2008). Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature chemical biology, 4(1), 33-41.

Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., … & Hong, C. C. (2008). Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PloS one, 3(8), e2904.

Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry & cell biology, 42(11), 1802-1807.

제품문의 메일보내기바이오젬스코리아 홈페이지 가기BioGems 홈페이지 가기
Dibutyryl-cAMP sodium salt ( cAMP Pathway Activator ) [ 1698950 ]

본 정보는 "바이오젬스코리아"(으)로 문의 바랍니다.

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