BAY 11-7082

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Size	Price
10mg	$95.00
25mg	$220.00

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Catalog Number : 1956772

description

Bay 11-7082는 TNF-α에 의해 유도되는 IκBα 인산화 및 유비퀴틴 결합을 선택적이고 비가역적으로 억제하는 물질입니다. 이 물질은 여러 B 및 T 림프종 세포주에서 세포사멸을 유도하고, TNF-α에 의해 유도되는 여러 접착 분자의 발현을 억제하는 것으로 보고되었습니다.

Additional Information

Applications:	FA
Synonyms:	(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Formulation:	Crystalline solid
Chemical Name:	(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile
Molecular Formula:	C₁₀H₉NO₂S
Molecular Weight:	207.3
CAS Number	19542-67-7
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Mori, N., Yamada, Y., Ikeda, S., Yamasaki, Y., Tsukasaki, K., Tanaka, Y., ... & Fujii, M. (2002). Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I–infected T-cell lines and primary adult T-cell leukemia cells. Blood, 100(5), 1828-1834. Lappas, M., Yee, K., Permezel, M., & Rice, G. E. (2005). Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-κB and IκB kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology, 146(3), 1491-1497. García, M. G., Alaniz, L., Lopes, E. C., Blanco, G., Hajos, S. E., & Alvarez, E. (2005). Inhibition of NF-κB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines. Leukemia research, 29(12), 1425-1434.

BAY 11-7082 ( NF-κB & IκBα Inhibitor ) [ 1956772 ] : BioGems Small Molecules

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