AS 8351

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Size	Price
10mg	$110.00
25mg	$235.00

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Catalog Number : 7964296

description

AS 8351은 KDM5B(JARID1B)를 표적으로 하는 철 킬레이트제이자 히스톤 탈메틸화효소 억제제입니다. 다른 소분자 물질과 병용 시 인간 섬유아세포의 심장 재프로그래밍을 효과적으로 유도하는 것으로 보고되었습니다. KDM5B는 여러 도메인을 가진 탈메틸화효소로, 다양한 암 유형에서 과발현됩니다.

Additional Information

Applications:	FA
Synonyms:	AS8351, AS-8351, NSC-51355, 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone
Formulation:	Crystalline solid
Chemical Name:	N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]pyridine-4-carbohydrazide
Molecular Formula:	C₁₇H₁₃N₃O₂
Molecular Weight:	291.3
CAS Number	796-42-9
Purity:	≥98%
Storage Conditions:	Product should be kept at -20°C.
References:	Cao, N., Huang, Y., Zheng, J., Spencer, C. I., Zhang, Y., Fu, J. D., ... & Ma, T. (2016). Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science, 352(6290), 1216-1220. Chen, Y., Yang, Z., Zhao, Z. A., & Shen, Z. (2017). Direct reprogramming of fibroblasts into cardiomyocytes. Stem cell research & therapy, 8(1), 118. Hayami, S., Yoshimatsu, M., Veerakumarasivam, A., Unoki, M., Iwai, Y., Tsunoda, T., ... & Ponder, B. A. (2010). Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. Molecular cancer, 9(1), 59.

AS 8351 ( KDM5B Inhibitor ) [ 7964296 ] : BioGems Small Molecules

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