[Creative-Biolabs] Anti-GPC3 (X8X137) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 | 연구용제품 > Bio마켓

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등록2026.08.04
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[Creative-Biolabs] Anti-GPC3 (X8X137) h(CD28-41BB-CD3ζ) CAR, pCDCAR1

분류 시약 > 기타
브랜드Creative-Biolabs
원산지미국

이메일 abbabio_cs@naver.com
연락처 02-428-6366

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안녕하세요. 아바바이오 싸이언스입니다. Creative Biolabs 의 제품을 소개해 드리겠습니다.

아바바이오는 Creative Biolabs의 공식 대리점입니다.

이 제품은 Anti-GPC3 (X8X137) h(CD28-41BB-CD3ζ) CAR, pCDCAR1 입니다.

#XS-0822-LX137 / Anti-GPC3 (X8X137) h(CD28-41BB-CD3ζ) CAR, pCDCAR1

아바바이오는 Creative Biolabs의 공식 대리점입니다.

Creative biolabs has developed Lentiviral CAR vector pCDCAR1 GPC3 (X8X137) h(28BBζ), which is constructed for the engineering of T cells to target human GPC3. The T cells are genetically modified through transduction with a Lentiviral vector expressing scFv of anti-GPC3 antibody linked to a CD28 transmembrane domain/ endodomain and CD137 (4-1BB), CD3-zeta signaling domains. And the vector product was designed for the treatment of Hepatocellular Carcinoma (HCC).

Specific Inquiry

Size: 10 μg 100 μg 500 μg 1 mg Other
Marker: NONE CAR-2A-GFP CAR-TAA-PGK-GFP CAR-2A-GFP-PGK-PuroR CAR-TAA-PGK-GFP-2A-PuroR CAR-2A-PuroR CAR-TAA-PGK-PuroR Other
Form: Liquid LYOPH

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Details

Target
GPC3

Targeting Cell Type
T cell

Targeting Diseases
Hepatocellular Carcinoma (HCC)

Generation
Third

Vector Name
pCDCAR1

Vector Length
~8kb

Vector Type
Lentiviral vector

Receptor Construction
scFv-CD28-41BB-CD3ζ

Discription of Signaling Cassetes
CD28
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
41BB
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ, ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric 4-1BB and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.