[Accegen] Human Orbital Fibroblasts | 연구용제품 > Bio마켓

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등록2026.05.27
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[Accegen] Human Orbital Fibroblasts

분류 Bio resource > Cell
브랜드Accegen
원산지USA

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제품 설명

Human Orbital Fibroblasts

제품 번호

ABC-TC077G

제품 특징

Description

Human Orbital Fibroblasts (HOFs) are primary cells isolated from human orbital connective tissue and cryopreserved following primary culture, and are commonly referenced in orbital and autoimmune research as representative primary fibroblasts, particularly in studies requiring non-transformed fibroblast models from ocular tissues. These fibroblasts exhibit a typical spindle-shaped morphology and adhere well in vitro. HOFs express markers such as vimentin, CD90, and TSH receptor (TSHR), and exhibit phenotypic plasticity that allows differentiation into adipocytes or myofibroblasts. They play an essential role in maintaining the structural integrity of orbital tissue and are actively involved in extracellular matrix remodeling. Research has shown their significant involvement in Graves’ ophthalmopathy (GO), where they respond to inflammatory stimuli by producing cytokines such as IL-6 and interact with endothelin receptors, contributing to disease pathogenesis. These characteristics make them valuable for studying orbital tissue biology and related autoimmune disorders. Repeated freezing and thawing should be avoided during culture to maintain cell viability and function.

Product Code	Human Orbital Fibroblasts, Orbital Fibroblasts, HOFs, Human Eye Socket Fibroblasts
Species	Human
Cat.No	ABC-TC077G
Product Category	Primary Cells
Size/Quantity	1 vial
Cell Type	Fibroblast
Growth Mode	Adherent
Shipping Info	Dry Ice
Growth Conditions	37 ℃, 5% CO₂
Source Organ	Orbital Tissue
Disease	Normal
Biosafety Level	1
Storage	Liquid Nitrogen
Product Type	Orbital Cells
Passage Number	P1

Quality Control

All cells test negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi.

Application

Human orbital fibroblasts are a vital model for investigating diseases related to the connective tissue of the orbit, such as Graves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy (TAO). These fibroblasts enable researchers to study the significant inflammation characteristic of these conditions, where tissues become infiltrated by activated T lymphocytes and mast cells, leading to the excessive accumulation of hyaluronan. Using human orbital fibroblasts allows the exploration of communication pathways between fibroblasts and immune cells, providing insights into the mechanisms driving inflammation and disease progression, which could inform potential therapeutic approaches.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).