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  • 등록2026.04.01
  • 조회45
InVivoMAb anti-mouse PD-1 (CD279) / in vivo 항체 전문 !!

InVivoMAb anti-mouse PD-1 (CD279) / in vivo 항체 전문 !!

본 정보는 "바이오엑스셀코리아"(으)로 문의 바랍니다.

BioXCell 은

In Vivo용 Antibody를 1mg,5mg,25mg,50mg,100mg 

용량으로 직접 제조하며, 합리적인 가격으로 공급하는 회사입니다. 

*** Cited in nearly 30,000 Publications !! ***



▶high quality 


▶bulk quantity (milligram to gram)  


▶low endotoxin levels  


▶well suited for in-vivo preclinical studies.  

  

BioXCell Best Product ! 


InVivoMAb anti-mouse PD-1 (CD279)

Catalog # BE0146

Clone RMP1-14 

SIZE:  1mg,5mg,25mg,50mg,100mg

 

Product Description

The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. PD-1 expression declines after successful elimination of antigen. Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals. PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is known to play key roles in peripheral tolerance and prevention of autoimmune disease in mice as PD-1 knockout animals show dilated cardiomyopathy, splenomegaly, and loss of peripheral tolerance. Induced PD-L1 expression is common in many tumors including squamous cell carcinoma, colon adenocarcinoma, and breast adenocarcinoma. PD-L1 overexpression results in increased resistance of tumor cells to CD8 T cell mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with antibodies which block the interaction between PD-L1 and its receptor PD-1. For these reasons anti-PD-1 mediated immunotherapies are currently being explored as cancer treatments. Like the J43 antibody the RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1.

Specifications

IsotypeRat IgG2a, κ
Recommended Isotype Control(s)InVivoMAb rat IgG2a isotype control, anti-trinitrophenol
Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
ConjugationThis product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
ImmunogenSyrian Hamster BKH cells transfected with mouse PD-1 cDNA
Reported Applicationsin vivo blocking of PD-1/PD-L signaling
in vitro Organoids/Organ-on-Chip
FormulationPBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin≤1EU/mg (≤0.001EU/μg)
Determined by LAL assay
Purity≥95%
Determined by SDS-PAGE
Sterility0.2 µm filtration
ProductionPurified from cell culture supernatant in an animal-free facility
PurificationProtein G
RRIDAB_10949053
Molecular Weight150 kDa
StorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
Need a Custom Formulation?See All Antibody Customization Options

매주 월, 목요일 4시 발주 1주 소요

자세한 문의사항은 본사로 문의해 주시기 바랍니다.

 바이오클론(주)


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• 2026년 2월 19일부터 바이오클론(BioClone)은 Bio X Cell의 공식 대리점으로서 견적, 주문 및 기술지원 관련 문의를 지원합니다. 관련 문의사항은 바이오클론(BioClone)으로 연락 주시면 안내해드리겠습니다.

• As an authorized distributor of Bio X Cell, BioClone will support inquiries related to quotations, orders, and technical services effective February 19, 2026. Customers may direct their inquiries to BioClone for assistance. 

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이에 관련 문의는 아래 바이오클론 연락처로 부탁 드립니다. 서비스 제공 범위 및 지원 절차는 기존과 동일합니다.
E-mail:  bioclone@bioclone.co.kr / Tel: 02-2690-0058
 
 
PD-1 in vivo Bioxcell RMP1-14 CD279

본 정보는 "바이오엑스셀코리아"(으)로 문의 바랍니다.

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