연구실에서는 다음과 같은 분야를 중심으로 연구를 수행하고 있습니다.
• 유전성 난청 및 평형질환의 원인 유전자 발굴 및 기능 규명
• Whole-genome sequencing 및 Multi-omics 기반 질환 분석
• 유전자 전달체(AAV, virus-like particle) 및 유전자 편집(CRISPR, Prime editing)을 이용한 치료제 개발
• 난청 치료를 위한 신약 및 분자 표적 치료제 개발
• 내이 면역반응 및 염증 기전 연구
• 동물모델을 이용한 전기생리학 및 행동학적 기능 평가
이를 위해 분자생물학, 유전학, 생화학, 세포생물학, 전기생리학, 동물실험 등 다양한 연구기법을 활용하고 있으며, 실제 치료제 개발로 이어질 수 있는 연구를 수행하고 있습니다.
관심 있는 학생들의 많은 지원을 바랍니다.
감사합니다.
<연구실대표논문>
1. Jang SH, Song HG, Joo SY, Kim JA, Kim SJ, Choi JY, Jung J*, Gee HY*. Gene supplementation with precise transgene expression rescues hearing loss in a mouse model with an Mpzl2 East Asian founder variant. Mol Ther. 2026 Jan 7;34(1):216-231. (*Co-corresponding author) IF = 11.4
2. Noh B, Gopalappa R, Lin H, Gee HY, Choi JY, Kim HH, Jung J. Engineered virus-like particles for in vivo gene editing ameliorate hearing loss in murine DFNA2 model. Mol Ther. 2025 Dec 3;33(12):6449-6462. IF = 11.4
3. Kim JA, Jang SH, Joo SY, Kim SJ, Choi JY, Jung J*, Gee HY*. Systematic genetic assessment of hearing loss using whole-genome sequencing identifies pathogenic variants. Exp Mol Med. 2025 Apr;57(4):775-787 (*Co-corresponding author). IF =17.5
4. Joo SY, Min H, Kim JA, Kim SJ, Jang SH, Lee H, Kim KM, Seong JK, Choi JY, Jung J*, Bok J*, Gee HY*. Biallelic variants of SEMA3F are associated with nonsyndromic hearing loss. Mol Cells. 2025 Mar;48(3):100190. (*Co-corresponding author) IF =8.2
5. Jung J, Joo SY, Min H, Roh JW, Kim KA, Ma JH, Rim JH, Kim JA, Kim SJ, Jang, SH, Koh YI, Kim HY, Lee H, Kim BC, Gee HY, Bok J, Choi JY, Seong JK. MYH1, deficiency disrupts outer hair cell electromotility, resulting in hearing loss., Exp Mol Med. 2024 Nov;56(11):2423-2435. IF =17.5
6. Kang M, Kim JA, Song MH, Joo SY, Kim SJ, Jang SH, Lee H, Seong JK, Choi JY, Gee HY, Jung J. Novel Variant in CEP250 Causes Protein Mislocalization and Leads to Nonsyndromic Autosomal Recessive Type of Progressive Hearing Loss. Cells. 2023 Sep 21;12(18):2328. IF =6.0
7. Jung J, Noh SH, Jo S, Song D, Kang MJ, Shin MH, Lee HJ, Pyun JC, Namkung W, Han G, Lee MG, Choi JY. Novel small molecule-mediated restoration of the surface expression and anion exchange activity of mutated pendrin causing Pendred syndrome and DFNB4. Biomed Pharmacother. 2023 Sep 8;167:115445. IF =7.5
8. Noh B, Rim JH, Gopalappa R, Lin H, Kim KM, Kang MJ, Gee HY, Choi JY, Kim HH, Jung J. In vivo outer hair cell gene editing ameliorates progressive hearing loss in dominant-negative Kcnq4 murine model. Theranostics. 2022 Feb 28;12(5):2465-2482. IF =14.9
9. Koh YI, Oh KS, Kim JA, Noh B, Choi HJ, Joo SY, Rim JH, Kim HY, Kim DY, Yu S, Kim DH, Lee SG, Jung J*, Choi JY*, Gee HY*. OSBPL2 mutations impair autophagy and lead to hearing loss, potentially remedied by rapamycin. Autophagy. 2022 Nov;18(11):2593-2614. (*Co-corresponding author) IF =18.6
10. Bae SH, Yoo JE, Choe YH, Kwak SH, Choi JY, Jung J*, Hyun Y-M*. Neutrophils infiltrate into the spiral ligament but not the stria vascularis in the cochlea during lipopolysaccharideinduced inflammation. Theranostics. 2021 Jan 1. 11(6):2522-2533. (Co-corresponding author) IF =14.9
11. Choi HJ, Lee HJ, Choi JY, Jeon IH, Noh B, Devkota S, Lee H-W, Eo SK, Choi JY, Lee MG, Jung J. DNAJC14 ameliorates inner ear degeneration in the DFNB4 mouse model. Mol Ther Methods Clin Dev. 2019 Nov 30;17:188-197 (Corresponding author) IF =5.0
12. Jung J*, Lin H*, Koh YI*, Ryu K, Lee JS, Rim JH, Choi HJ, Lee HJ, Kim H-Y, Yu S, Jin H, Lee JH, Lee MG, Namkung W, Choi JY, Gee HY. Rare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment. Exp Mol Med. 2019;51:99 IF =17.5
13. Jung J*, Yoo JE*, Choe YH, Park SC, Lee HJ, Lee HJ, Noh B, Kim SH, Kang G-Y, Lee K-M, Yoon SS, Jang DS, Yoon J-H, Hyun Y-M, Choi JY. Cleaved Cochlin Sequesters Pseudomonas Aeruginosa and Activates Innate Immunity in the Inner Ear. Cell Host & Microbe. 2019 Apr 10;25:1-13 IF =23.2
14. Jung J, Kim J, Roh SH, Jun I, Sampson DR, Gee HY, Choi JY, Lee MG. The HSP70 co-chaperone DNAJC14 targets misfolded pendrin for unconventional protein secretion. Nat Commun. 2016 Apr 25;8:11386. IF =18.1