BRIC Home 회원가입 로그인
BRICWebinar학술 웨비나란 PC 또는 모바일 기기를 통해 접속하는 세미나입니다.   
웨비나란? 학술웨비나 기업기술웨비나 문의
Webinar 접속기기 안내
Window/Mac 운영체제의 PC/노트북
학술웨비나 - 연구성과
Integrative Structure and Functional Anatomy of a Nuclear Pore Complex [Nature]
김승중
 일시 
   2018년 5월 18일 (금) 오후 2시 (한국시간)
 연사 
   김승중 (University of California, San Francisco (UCSF))
 약력 
  PDF (341 KB)
세미나 개요
Despite the central role of Nuclear Pore Complexes (NPCs) as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm, their large size and dynamic nature have impeded a full structural and functional elucidation. Here, we have determined a subnanometer precision structure for the entire 552-protein yeast NPC by satisfying diverse data including stoichiometry, a cryo-electron tomography map, chemical cross-links, and small angle X-ray scattering. The structure reveals the NPC’s functional elements in unprecedented detail. The NPC is built of sturdy diagonal columns to which are attached connector cables, imbuing both strength and flexibility, while tying together all other elements of the NPC, including membrane-interacting regions and RNA processing platforms. Inwardly-directed anchors create a high density of transport factor-docking Phe-Gly repeats in the central channel, organized in distinct functional units. Taken together, this integrative structure allows us to rationalize the architecture, transport mechanism, and evolutionary origins of the NPC.

세미나 보기


관련논문 보기
Integrative structure and functional anatomy of a nuclear pore complex
Nature, Published: 14 March 2018 | doi:10.1038/nature26003
목록
Copyright © BRIC. All rights reserved. Contact member@ibric.org