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정종진
정종진 (Jong Jin Jeong) 저자 이메일 보기
The University of Chicago
조회 286  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Cytokine regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis
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Abstract

Even though the TET enzymes catalyze the generation of 5-hydroxymethyl-cytosines required for lineage commitment and subsequent differentiation of stem cells into erythroid cells, the mechanisms that link extra-cellular signals to TET activation and DNA hydroxymethylation are unknown. We demonstrate that hematopoietic cytokines phosphorylate TET2 leading to its activation in erythroid progenitors. Specifically, cytokine receptor associated, JAK2, phosphorylates TET2 at tyrosines 1939 and 1964. Phosphorylated TET2 interacts with erythroid transcription factor, KLF1, and this interaction with TET2 is increased upon exposure to erythropoietin. The activating JAK2V617F mutation seen in myeloproliferative disease patient samples and in mouse models is associated with increased TET activity and cytosine hydroxymethylation as well as genome wide loss of cytosine methylation. These epigenetic and functional changes are also associated with increased expression of several oncogenic transcripts. Thus, we demonstrate that JAK2 mediated TET2 phosphorylation provides a mechanistic link between extracellular signals and epigenetic changes during hematopoiesis.

논문정보
- 형식: Research article
- 게재일: 2019년 04월 (BRIC 등록일 2019-04-09)
- 연구진: 국외연구진
- 분야: Cancer Biology/Oncology
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Cancer Biology/Oncology

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Google (by Jong Jin Jeong)
Pubmed (by Jong Jin Jeong)
프리미엄 Bio일정 Bio일정 프리미엄 안내
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
날짜: 2019.05.09
장소: 판교 차바이오컴플렉스 국제회의실
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