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조성호 (Seong H. Cho) 저자 이메일 보기
경희대학교 의과대학, University of South Florida
 
조회 297  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Soy isoflavones reduce asthma exacerbation in asthmatics with high PAI-1 producing genotypes
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Abstract

Background
The 4G4G genotype of plasminogen activator inhibitor-1 (PAI-1) is associated with increased plasma PAI-1 levels and poor asthma control. Previous studies suggest that soy isoflavones may reduce PAI-1 levels.

Objective
We sought to investigate PAI-1 genotype-specific differences of the soy isoflavone response in asthma outcomes.

Methods
A PAI-1 functional polymorphism (rs1799768, 4G5G) was characterized in subjects with poorly controlled asthma enrolled in a randomized clinical trial of soy isoflavones (n=265). Genotype-specific treatment responses on asthma outcomes were compared between soy isoflavones versus placebo. Normal human bronchial epithelial cells (NHBE) were cultured with or without TGF-β1 and/or genistein, and PAI-1 levels were measured.

Results
The 4G4G/4G5G genotype was associated with a higher risk for allergy-related worsened asthma symptoms and eczema at baseline compared to the 5G5G genotype. There was a significant interaction between the genotype and soy isoflavone intervention on oral corticosteroid use for asthma exacerbation (p=0.005). In a subgroup analysis, soy isoflavones significantly reduced the use of oral corticosteroids (number of events/person-year) by four-fold compared to the placebo in the 4G4G/4G5G genotype (0.2 vs 0.8, relative risk 0.28, p <0.001) but not in the 5G5G genotype. Soy isoflavones reduced plasma PAI-1 levels compared to the placebo. Genistein treatment reduced TGF-β1-induced PAI-1 production in NHBE.

Conclusions
This study demonstrates that soy isoflavone treatment provides a significant benefit in reducing the number of severe asthma exacerbations in asthmatic subjects with the high PAI-1 producing genotype. PAI-1 polymorphisms can be used as a genetic biomarker for soy isoflavone responsive subjects with asthma.

Key words: soy isoflavones, genistein, asthma, exacerbation, PAI-1, polymorphisms 

논문정보
- 형식: Research article
- 게재일: 2019년 01월 (BRIC 등록일 2019-02-01)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Immunology
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관련인물
김대우 (서울대학교 의과대학)
김동규 (한림대학교 의과대학)
관련분야 논문보기
Immunology

외부링크
Google (by Seong H. Cho)
Pubmed (by Seong H. Cho)
프리미엄 Bio일정 Bio일정 프리미엄 안내
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
날짜: 2019.05.09
장소: 판교 차바이오컴플렉스 국제회의실
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