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김승진 (Seung-Jin Kim) 저자 이메일 보기
National Institutes of Health
조회 841  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Adipocyte death preferentially induces liver injury and inflammation via the activation of CCR2+ macrophages and lipolysis
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Adipocyte death occurs under various physiopathological conditions, including obesity and alcohol drinking, and can trigger organ damage particularly in the liver, but the underlying mechanisms remain obscure. To explore these mechanisms, we developed a mouse model of inducible adipocyte death by overexpressing the human CD59 (hCD59) on adipocytes (adipocyte-specific hCD59 transgenic mice). Injection of these mice with intermedilysin (ILY), which rapidly lyses hCD59 expressing cells exclusively by binding to the hCD59 but not mouse CD59, resulted in the acute selective death of adipocytes, adipose macrophage infiltration, and elevation of serum free fatty acid (FFA) levels. ILY injection also resulted in the secondary damage to multiple organs with the strongest injury observed in the liver, with inflammation and hepatic macrophage activation. Mechanistically, acute adipocyte death elevated epinephrine and norepinephrine levels and activated lipolysis pathways in adipose tissue in a CCR2+ macrophage?dependent manner, which was followed by FFA release and lipotoxicity in the liver. Additionally, acute adipocyte death caused hepatic CCR2+ macrophage activation and infiltration, further exacerbating liver injury. Conclusion: Adipocyte death predominantly induces liver injury and inflammation, which is probably due to the superior sensitivity of hepatocytes to lipotoxicity and the abundance of macrophages in the liver.

- 형식: Research article
- 게재일: 2019년 01월 (BRIC 등록일 2019-02-01)
- 연구진: 국내+국외 연구진
- 분야: Medicine
  댓글 2
회원작성글 vetknu  (2019-02-08 13:47)
김박사님. 그간 수고에 축하드립니다. ^^
회원작성글 KSP  (2019-02-12 12:23)
축하한다~ 승진! 조만간 한국서 보자고!
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날짜: 2019.05.09
장소: 판교 차바이오컴플렉스 국제회의실
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