[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
스폰서배너광고 안내  배너1 배너2
전체보기 추천논문 상위피인용논문 인터뷰 그이후 한빛사통계
장유수 (Yoosoo Chang) 저자 이메일 보기
성균관대학교 의과대학, 강북삼성병원
조회 423  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Alcoholic and Nonalcoholic Fatty Liver Disease and Liver-Related Mortality: A Cohort Study
열기 Authors and Affiliations


We compared liver-related mortality by fibrosis severity between 2 types of fatty liver disease (FLD), nonalcoholic FLD (NAFLD) and alcoholic FLD (AFLD), in a large cohort of nonobese and obese individuals.

A cohort study was performed with 437,828 Korean adults who were followed up for up to 14 years. Steatosis was diagnosed based on ultrasonography; fibrosis severity was determined by the fibrosis 4 (FIB-4) score. Vital status and liver-related deaths were ascertained through linkage to national death records.

The prevalence of NAFLD and AFLD was 20.9% and 4.0%, respectively. During 3,145,541.1 person-years of follow-up, 109 liver-related deaths were identified (incidence rate of 3.5 per 105 person-years). When changes in fatty liver status, FIB-4 scores, and confounders during follow-up were updated as time-varying covariates, compared with the reference (absence of both excessive alcohol use and FLD), the multivariable-adjusted hazard ratios with 95% confidence intervals for liver-related mortality among those with low, intermediate, and high FIB-4 scores were 0.43 (0.19?0.94), 2.74 (1.23?6.06), and 84.66 (39.05?183.54), respectively, among patients with NAFLD, whereas among patients with AFLD, the corresponding hazard ratios (95% confidence intervals) were 0.67 (0.20?2.25), 5.44 (2.19?13.49), and 59.73 (27.99?127.46), respectively. The associations were more evident in nonobese individuals than in obese individuals (P for interaction = 0.004).

In this large cohort of young and middle-aged individuals, NAFLD and AFLD with intermediate to high fibrosis scores were associated with an increased risk of liver-related mortality in a dose-dependent manner, especially among nonobese individuals.

- 형식: Research article
- 게재일: 2019년 01월 (BRIC 등록일 2019-01-31)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Medicine
  댓글 0
(주) 코리아바이오믹스
장유수 님 전체논문보기 >
김보경 (강북삼성병원)
김재헌 (순천향대학교 서울병원 비...)
류승호 (성균관대학교 의과대학, 강...)
정현숙 (성균관대학교 의과대학, 강...)
조용균 (성균관대학교 의과대학, 강...)
주관중 (성균관대학교 의과대학, 강...)
주은정 (성균관대학교 의과대학, 강...)
관련분야 논문보기

Google (by Yoosoo Chang)
Pubmed (by Yoosoo Chang)
프리미엄 Bio일정 Bio일정 프리미엄 안내
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
날짜: 2019.05.09
장소: 판교 차바이오컴플렉스 국제회의실
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북   유튜브 유튜브    RSS서비스 RSS