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장유수
장유수 (Yoosoo Chang) 저자 이메일 보기
성균관대학교 의과대학, 강북삼성병원
 
조회 326  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Alcoholic and Nonalcoholic Fatty Liver Disease and Liver-Related Mortality: A Cohort Study
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Abstract

OBJECTIVES:
We compared liver-related mortality by fibrosis severity between 2 types of fatty liver disease (FLD), nonalcoholic FLD (NAFLD) and alcoholic FLD (AFLD), in a large cohort of nonobese and obese individuals.

METHODS:
A cohort study was performed with 437,828 Korean adults who were followed up for up to 14 years. Steatosis was diagnosed based on ultrasonography; fibrosis severity was determined by the fibrosis 4 (FIB-4) score. Vital status and liver-related deaths were ascertained through linkage to national death records.

RESULTS:
The prevalence of NAFLD and AFLD was 20.9% and 4.0%, respectively. During 3,145,541.1 person-years of follow-up, 109 liver-related deaths were identified (incidence rate of 3.5 per 105 person-years). When changes in fatty liver status, FIB-4 scores, and confounders during follow-up were updated as time-varying covariates, compared with the reference (absence of both excessive alcohol use and FLD), the multivariable-adjusted hazard ratios with 95% confidence intervals for liver-related mortality among those with low, intermediate, and high FIB-4 scores were 0.43 (0.19?0.94), 2.74 (1.23?6.06), and 84.66 (39.05?183.54), respectively, among patients with NAFLD, whereas among patients with AFLD, the corresponding hazard ratios (95% confidence intervals) were 0.67 (0.20?2.25), 5.44 (2.19?13.49), and 59.73 (27.99?127.46), respectively. The associations were more evident in nonobese individuals than in obese individuals (P for interaction = 0.004).

CONCLUSIONS:
In this large cohort of young and middle-aged individuals, NAFLD and AFLD with intermediate to high fibrosis scores were associated with an increased risk of liver-related mortality in a dose-dependent manner, especially among nonobese individuals.

논문정보
- 형식: Research article
- 게재일: 2019년 01월 (BRIC 등록일 2019-01-31)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Medicine
RNF20/40 의존적 eEF1BδL 모노유비퀴틴화에 의한 열충격 유전자 전사 조절[Nucleic Acids Res.]
인선아
발표: 인선아 (KAIST)
일자: 2019년 2월 22일 (금) 오후 02시 (한국시간)
언어: 한국어
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Google (by Yoosoo Chang)
Pubmed (by Yoosoo Chang)
프리미엄 Bio일정 Bio일정 프리미엄 안내
2019 Korean Researchers’ Night in AACR 참가 신청 안내 (미국 애틀랜타)
2019 Korean Researchers’ Night in AACR 참가 신청 안내 (미국 애틀랜타)
사전접수: ~2019.02.20
날짜: 2019.03.31
장소: Atlanta Marriott Marquis
[BRIC Webinar]RNF20/40 의존적 eEF1BδL 모노유비퀴틴화에 의한 열충격 유전자 전사 조절-인선아 (KAIST)
2019 서경배과학재단 신진과학자 연구지원 프로그램 공고
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