[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
스폰서배너광고 안내  배너1 배너2
전체보기 추천논문 상위피인용논문 인터뷰 그이후 한빛사통계
임정아
임정아 (Jung-Ah Lim) 저자 이메일 보기
서울대학교병원, 한림대학교 의과대학
 
조회 366  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Development of the Clinical Assessment Scale in Autoimmune Encephalitis (CASE)
열기 Authors and Affiliations

Abstract

Objective
There is no scale for rating the severity of autoimmune encephalitis (AE). In this study, we aimed to develop a novel scale for rating severity in patients with diverse AE syndromes and to verify the reliability and validity of the developed scale.

Methods
The key items were generated by a panel of experts and selected according to content validity ratios. The developed scale was initially applied to 50 patients with AE (development cohort) to evaluate its acceptability, reproducibility, internal consistency, and construct validity. Then, the scale was applied to another independent cohort (validation cohort, n=38).

Results
A new scale consisting of 9 items (seizure, memory dysfunction, psychiatric symptoms, consciousness, language problems, dyskinesia/dystonia, gait instability and ataxia, brainstem dysfunction, and weakness) was developed. Each item was assigned a value of up to 3 points. The total score could therefore range from 0 to 27. We named the scale the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). The new scale showed excellent interobserver (ICC = 0.97) and intraobserver (ICC = 0.96) reliability for total scores, was highly correlated with mRS (r = 0.86, p<0.001), and had acceptable internal consistency (Cronbach's alpha = 0.88). Additionally, in the validation cohort, the scale showed high interobserver reliability (ICC = 0.99) and internal consistency (Cronbach's alpha = 0.92).

Interpretation
CASE is a novel clinical scale for AE with a high level of clinimetric properties. It would be suitable for application in clinical practice and might help overcome the limitations of current outcome scales for AE.

논문정보
- 형식: Research article
- 게재일: 2019년 01월 (BRIC 등록일 2019-01-28)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Neuroscience
  댓글 0
등록
 
목록
동일바이오테크
관련링크
임정아 님 전체논문보기 >
관련인물
이상건 (서울대학교 의과대학)
이순태 (서울대학교 의과대학)
주건 (서울대학교 의과대학)
관련분야 논문보기
Neuroscience

외부링크
Google (by Jung-Ah Lim)
Pubmed (by Jung-Ah Lim)
프리미엄 Bio일정 Bio일정 프리미엄 안내
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
제2회 오가노이드 심포지엄 및 핸즈온워크샵 [2019 CHA Organoid Center Symposium]
날짜: 2019.05.09
장소: 판교 차바이오컴플렉스 국제회의실
위로가기
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북   유튜브 유튜브    RSS서비스 RSS
에펜도르프코리아