[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
대학원 진학 설문조사
스폰서배너광고 안내  배너1
전체보기 한빛사논문 상위피인용논문 인터뷰 그이후 한빛사통계
황영선 (Young Sun Hwang) 저자 이메일 보기
조회 720  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Zygotic gene activation in the chicken occurs in two waves, the first involving only maternally derived genes
열기 Authors and Affiliations


The first wave of transcriptional activation occurs after fertilisation in a species-specific pattern. Despite its importance to initial embryonic development, the characteristics of transcription following fertilisation are poorly understood in Aves. Here, we report detailed insights into the onset of genome activation in chickens. We established that two waves of transcriptional activation occurred, one shortly after fertilisation and another at Eyal-Giladi and Kochav Stage V. We found 1544 single nucleotide polymorphisms across 424 transcripts derived from parents that were expressed in offspring during the early embryonic stages. Surprisingly, only the maternal genome was activated in the zygote, and the paternal genome remained silent until the second-wave, regardless of the presence of a paternal pronucleus or supernumerary sperm in the egg. The identified maternal genes involved in cleavage that were replaced by bi-allelic expression. The results demonstrate that only maternal alleles are activated in the chicken zygote upon fertilisation, which could be essential for early embryogenesis and evolutionary outcomes in birds.

- 형식: Research article
- 게재일: 2018년 10월 (BRIC 등록일 2018-11-29)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Developmental_Biology, Genetics, Genomics
- 추천: Deivendran Rengaraj (서울대학교)
- 추천사유: This paper firstly demonstrated the avian-specific features of zygotic genome activation. Activating genes inside the zygote so that they can take control of development is known as zygotic genome activation. Despite the fact that birds are often used to study how embryos develop, zygotic genome activation in birds is not well understood. Fertilization in birds, including chickens, is different to mammals in that it requires multiple sperm to fertilize an egg cell. As such, zygotic genome activation in birds is likely to differ from that in mammals. In this paper, there are two stages of zygotic genome activation in chickens. The genes derived from the mother become active in the first stage, while genes from the father become active in the second stage. Genome activation in birds is therefore very different to the same process in mammals, which involves genome activation of both parents from the first stage. This extra level of control may help to prevent genetic complications resulting from the presence of multiple sperm, each of which carries a different set of genes from the father.
  댓글 0
황영선 님 전체논문보기 >
서민석 (Harvard Medical School)
한재용 (서울대학교)
관련분야 논문보기



Google (by Young Sun Hwang)
Pubmed (by Young Sun Hwang)
프리미엄 Bio일정 Bio일정 프리미엄 안내
19th Avison Biomedical Symposium 2019
19th Avison Biomedical Symposium 2019
사전접수: ~2019.05.27
날짜: 2019.05.31~06.01
장소: 서대문구 연세로 50-1 신촌세브란스병원 은명대강당
의료기기 GMP의 이해과정(재직자 과정)
의료기기 GMP의 이해과정(재직자 과정)
날짜: 2019.06.18~20
장소: 경기도 성남시 분당구 판교로289번길 20 스타트업캠퍼스 2층 세미나실2
제6회 KXA(대한 이종이식 연구회) 심포지엄
제6회 KXA(대한 이종이식 연구회) 심포지엄
날짜: 2019.05.30
장소: 서울대학교 의과대학 삼성암연구동 2층 이건희홀
비임상시험 계획서 및 보고서 Review 과정(재직자 과정)
비임상시험 계획서 및 보고서 Review 과정(재직자 과정)
날짜: 2019.05.29~31
장소: 경기도 성남시 분당구 판교로289번길 20 스타트업캠퍼스 2층 세미나실1
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북   유튜브 유튜브    RSS서비스 RSS