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황영선 (Young Sun Hwang) 저자 이메일 보기
서울대학교
 
조회 720  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Zygotic gene activation in the chicken occurs in two waves, the first involving only maternally derived genes
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Abstract

The first wave of transcriptional activation occurs after fertilisation in a species-specific pattern. Despite its importance to initial embryonic development, the characteristics of transcription following fertilisation are poorly understood in Aves. Here, we report detailed insights into the onset of genome activation in chickens. We established that two waves of transcriptional activation occurred, one shortly after fertilisation and another at Eyal-Giladi and Kochav Stage V. We found 1544 single nucleotide polymorphisms across 424 transcripts derived from parents that were expressed in offspring during the early embryonic stages. Surprisingly, only the maternal genome was activated in the zygote, and the paternal genome remained silent until the second-wave, regardless of the presence of a paternal pronucleus or supernumerary sperm in the egg. The identified maternal genes involved in cleavage that were replaced by bi-allelic expression. The results demonstrate that only maternal alleles are activated in the chicken zygote upon fertilisation, which could be essential for early embryogenesis and evolutionary outcomes in birds.

논문정보
- 형식: Research article
- 게재일: 2018년 10월 (BRIC 등록일 2018-11-29)
- 연구진: 국내(교신)+국외 연구진태극기
- 분야: Developmental_Biology, Genetics, Genomics
- 추천: Deivendran Rengaraj (서울대학교)
- 추천사유: This paper firstly demonstrated the avian-specific features of zygotic genome activation. Activating genes inside the zygote so that they can take control of development is known as zygotic genome activation. Despite the fact that birds are often used to study how embryos develop, zygotic genome activation in birds is not well understood. Fertilization in birds, including chickens, is different to mammals in that it requires multiple sperm to fertilize an egg cell. As such, zygotic genome activation in birds is likely to differ from that in mammals. In this paper, there are two stages of zygotic genome activation in chickens. The genes derived from the mother become active in the first stage, while genes from the father become active in the second stage. Genome activation in birds is therefore very different to the same process in mammals, which involves genome activation of both parents from the first stage. This extra level of control may help to prevent genetic complications resulting from the presence of multiple sperm, each of which carries a different set of genes from the father.
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관련인물
서민석 (Harvard Medical School)
한재용 (서울대학교)
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Developmental_Biology

Genetics

Biochemistry

외부링크
Google (by Young Sun Hwang)
Pubmed (by Young Sun Hwang)
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