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전체보기 추천논문 상위피인용논문 인터뷰 그이후 한빛사통계
이승연
이승연 (Seung-Yon Lee) 저자 이메일 보기
Washington University School of Medicine, St. Louis
 
조회 403  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Glucose metabolism induced by Bmp signaling is essential for murine skeletal development
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Abstract

Much of the mammalian skeleton originates from a cartilage template eventually replaced by bone via endochondral ossification. Despite much knowledge about growth factors and nuclear proteins in skeletal development, little is understood about the role of metabolic regulation. Here we report that genetic deletion of the glucose transporter Glut1 (Slc2a1), either before or after the onset of chondrogenesis in the limb, severely impairs chondrocyte proliferation and hypertrophy, resulting in dramatic shortening of the limbs. The cartilage defects are reminiscent to those caused by deficiency in Bmp signaling. Importantly, deletion of Bmpr1a in chondrocytes markedly reduces Glut1 levels in vivo, whereas recombinant BMP2 increases Glut1 mRNA and protein levels, boosting glucose metabolism in primary chondrocytes. Biochemical studies identify a Bmp-mTORC1-Hif1a signaling cascade resulting in upregulation of Glut1 in chondrocytes. The results therefore uncover a hitherto unknown connection between Bmp signaling and glucose metabolism in the regulation of cartilage development.

논문정보
- 형식: Research article
- 게재일: 2018년 11월 (BRIC 등록일 2018-11-28)
- 연구진: 국외연구진

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