[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
버그알림
스폰서배너광고 안내  배너1 배너2
전체보기 추천논문 상위피인용 인터뷰 그이후 한빛사통계
사진없음
권민정 (Min Jung Kwun) 저자 이메일 보기
Imperial College London
 
조회 206  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Excision-reintegration at a pneumococcal phase-variable restriction-modification locus drives within- and between-strain epigenetic differentiation and inhibits gene acquisition
열기 Authors and Affiliations

Abstract
Phase-variation of Type I restriction-modification systems can rapidly alter the sequence motifs they target, diversifying both the epigenetic patterns and endonuclease activity within clonally descended populations. Here, we characterize the Streptococcus pneumoniae SpnIV phase-variable Type I RMS, encoded by the translocating variable restriction (tvr) locus, to identify its target motifs, mechanism and regulation of phase variation, and effects on exchange of sequence through transformation. The specificity-determining hsdS genes were shuffled through a recombinase-mediated excision-reintegration mechanism involving circular intermediate molecules, guided by two types of direct repeat. The rate of rearrangements was limited by an attenuator and toxin-antitoxin system homologs that inhibited recombinase gene transcription. Target motifs for both the SpnIV, and multiple Type II, MTases were identified through methylation-sensitive sequencing of a panel of recombinase-null mutants. This demonstrated the species-wide diversity observed at the tvr locus can likely specify nine different methylation patterns. This will reduce sequence exchange in this diverse species, as the native form of the SpnIV RMS was demonstrated to inhibit the acquisition of genomic islands by transformation. Hence the tvr locus can drive variation in genome methylation both within and between strains, and limits the genomic plasticity of S. pneumoniae.
논문정보
- 형식: Research article
- 게재일: 2018년 10월 (BRIC 등록일 2018-11-01)
- 연구진: 국외연구진
- 분야: Bioinformatics
  댓글 0
등록
 
목록
지이헬스케어
관련링크
권민정 님 전체논문보기 >
관련분야 논문보기
Bioinformatics

외부링크
Google (by Min Jung Kwun)
Pubmed (by Min Jung Kwun)
프리미엄 Bio일정 Bio일정 프리미엄 안내
2018 Ajou Biomedical International Symposium / Genoproteomic Signature of Human Diseases
2018 Ajou Biomedical International Symposium / Genoproteomic Signature of Human Diseases
날짜: 2018.11.26
장소: 아주대학교의료원 별관 대강당 (수원)
Human Genome Meeting 2019
Human Genome Meeting 2019
초록접수: ~2018.12.31
사전접수: ~2018.12.31
날짜: 2019.04.24~26
장소: 이화여자대학교 삼성홀
International Forum on Medical Innovation of Cell & Bio Therapy
International Forum on Medical Innovation of Cell & Bio Therapy
사전접수: ~2018.11.21
날짜: 2018.11.23
장소: 서울대학교병원 의생명연구원 1층 강당(대학로 소재)
[K-Genome Symposium 2018] 유전체, 헬스빅데이터, 그리고 정밀의료
[K-Genome Symposium 2018] 유전체, 헬스빅데이터, 그리고 정밀의료
날짜: 2018.11.19
장소: 아주대학교의료원 별관 대강당
위로가기
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북    RSS서비스 RSS