[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
버그알림
스폰서배너광고 안내  배너1 배너2 배너3
전체보기 추천논문 상위피인용 인터뷰 그이후 한빛사통계
김낙원
김낙원 (Nak Won Kim) 저자 이메일 보기
성균관대학교
 
조회 377  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles
열기 Authors and Affiliations

Abstract
Efficient delivery of tumor antigens and immunostimulatory adjuvants into lymph nodes is crucial for the maturation and activation of antigen-presenting cells (APCs), which subsequently induce adaptive antitumor immunity. A dissolving microneedle (MN) has been considered as an attractive method for transcutaneous immunization due to its superior ability to deliver vaccines through the stratum corneum in a minimally invasive manner. However, because dissolving MNs are mostly prepared using water-soluble sugars or polymers for their rapid dissolution in intradermal fluid after administration, they are often difficult to formulate with poorly water-soluble vaccine components. Here, we develop amphiphilic triblock copolymer-based dissolving MNs in situ that generate nanomicelles (NMCs) upon their dissolution after cutaneous application, which facilitate the efficient encapsulation of poorly water-soluble Toll-like receptor 7/8 agonist (R848) and the delivery of hydrophilic antigens. The sizes of NMCs range from 30 to 40 nm, which is suitable for the efficient delivery of R848 and antigens to lymph nodes and promotion of cellular uptake by APCs, minimizing systemic exposure of the R848. Application of MNs containing tumor model antigen (OVA) and R848 to the skin of EG7-OVA tumor-bearing mice induced a significant level of antigen-specific humoral and cellular immunity, resulting in significant antitumor activity.

Keywords: cancer vaccine; dissolving microneedle; lymphatic delivery; nanomicelle; Toll-like receptor agonist
논문정보
- 형식: Research article
- 게재일: 2018년 08월 (BRIC 등록일 2018-09-05)
- 연구진: 국내연구진태극기
  댓글 0
등록
 
목록
Springer Nature
관련링크
김낙원 님 전체논문보기 >
관련인물
김선영 (성균관대학교)
이민상 (성균관대학교)
임용택 (성균관대학교)
정지훈 (성균관대학교 약학대학)
외부링크
Google (by Nak Won Kim)
Pubmed (by Nak Won Kim)
프리미엄 Bio일정 Bio일정 프리미엄 안내
2018 Ajou Biomedical International Symposium / Genoproteomic Signature of Human Diseases
2018 Ajou Biomedical International Symposium / Genoproteomic Signature of Human Diseases
날짜: 2018.11.26
장소: 아주대학교의료원 별관 대강당 (수원)
Human Genome Meeting 2019
Human Genome Meeting 2019
초록접수: ~2018.12.31
사전접수: ~2018.12.31
날짜: 2019.04.24~26
장소: 이화여자대학교 삼성홀
International Forum on Medical Innovation of Cell & Bio Therapy
International Forum on Medical Innovation of Cell & Bio Therapy
사전접수: ~2018.11.21
날짜: 2018.11.23
장소: 서울대학교병원 의생명연구원 1층 강당(대학로 소재)
위로가기
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북    RSS서비스 RSS