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대메뉴안내: 한빛사
한빛사논문 추천논문 상위피인용논문 한빛사인터뷰 한빛사그이후
황태영
황태영 (Michael Taeyoung Hwang) 저자 이메일 보기
University of California, San Diego
 
조회 256  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Highly specific SNP detection using 2D graphene electronics and DNA strand displacement
열기 Authors and Affiliations

Abstract
Single-nucleotide polymorphisms (SNPs) in a gene sequence are markers for a variety of human diseases. Detection of SNPs with high specificity and sensitivity is essential for effective practical implementation of personalized medicine. Current DNA sequencing, including SNP detection, primarily uses enzyme-based methods or fluorophore-labeled assays that are time-consuming, need laboratory-scale settings, and are expensive. Previously reported electrical charge-based SNP detectors have insufficient specificity and accuracy, limiting their effectiveness. Here, we demonstrate the use of a DNA strand displacement-based probe on a graphene field effect transistor (FET) for high-specificity, single-nucleotide mismatch detection. The single mismatch was detected by measuring strand displacement-induced resistance (and hence current) change and Dirac point shift in a graphene FET. SNP detection in large double-helix DNA strands (e.g., 47 nt) minimize false-positive results. Our electrical sensor-based SNP detection technology, without labeling and without apparent cross-hybridization artifacts, would allow fast, sensitive, and portable SNP detection with single-nucleotide resolution. The technology will have a wide range of applications in digital and implantable biosensors and high-throughput DNA genotyping, with transformative implications for personalized medicine.
논문정보
- 형식: Research article
- 게재일: 2016년 06월 (BRIC 등록일 2017-04-16)
- 연구진: 국외연구진
- 분야: Nanobio, Biotechnology, Genetics
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에펜도르프(T:1577-4395)
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Nanobio

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Google (by Michael Taeyoung Hwang)
Pubmed (by Michael Taeyoung Hwang)
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날짜: 2017.05.24~25
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