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김인해 (Inhae Kim) 저자 이메일 보기
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조회 2619  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Linear Motif-Mediated Interactions Have Contributed to the Evolution of Modularity in Complex Protein Interaction Networks
Inhae Kim1, Heetak Lee1, Seong Kyu Han1, Sanguk Kim1,2*

1 Department of Life Sciences, Pohang University of Science and Technology, Pohang, Korea, 2 School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea

Abstract
The modular architecture of protein-protein interaction (PPI) networks is evident in diverse species with a wide range of complexity. However, the molecular components that lead to the evolution of modularity in PPI networks have not been clearly identified. Here, we show that weak domain-linear motif interactions (DLIs) are more likely to connect different biological modules than strong domain-domain interactions (DDIs). This molecular division of labor is essential for the evolution of modularity in the complex PPI networks of diverse eukaryotic species. In particular, DLIs may compensate for the reduction in module boundaries that originate from increased connections between different modules in complex PPI networks. In addition, we show that the identification of biological modules can be greatly improved by including molecular characteristics of protein interactions. Our findings suggest that transient interactions have played a unique role in shaping the architecture and modularity of biological networks over the course of evolution.

논문정보 F1000선정
- 형식: Research article
- 게재일: 2014년 10월 (BRIC 등록일 2015-12-16)
- 연구진: 국내연구진태극기
- 분야: Bioinformatics
- 추천: Faculty of 1000 Biology
- 추천사유: F1000Prime Recommendations, Dissents and Comments for [Kim I et al., PLoS Comput Biol 2014, 10(10):e1003881]. In F1000Prime, 14 Dec 2015; F1000Prime.com/720591107
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