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This issue's Research Highlights (01-7 December 2017)
생명과학 BRIC (2017-12-07 13:53)
Research Highlights from the Nature

Cancer-promoting cells are bred in the bone
Science (2017)
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils
Bone has a well-established role in advanced cancer. It provides a supportive microenvironment for the growth of metastatic cells that escape the primary tumor, which ultimately leads to loss of bone mass. Engblom et al. show that bone may also contribute to early-stage tumorigenesis through a mechanism that leads to an increase in bone mass (see the Perspective by Zhang and Lyden)...

Numerous genes shape ear lobes
Am. J. Human Genet. (2017)
Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment
The genetic basis of earlobe attachment has been a matter of debate since the early 20th century, such that geneticists argue both for and against polygenic inheritance. Recent genetic studies have identified a few loci associated with the trait, but large-scale analyses are still lacking. Here, we performed a genome-wide association study of lobe attachment in a multiethnic sample of 74,660 individuals from four cohorts (three with the trait scored by an expert rater and one with the trait self-reported)...

‘Yetis’ prove themselves elusive once again
Proc. R. Soc. B (2017)
Evolutionary history of enigmatic bears in the Tibetan Plateau–Himalaya region and the identity of the yeti
Although anecdotally associated with local bears (Ursus arctos and U. thibetanus), the exact identity of ‘hominid’-like creatures important to folklore and mythology in the Tibetan Plateau–Himalaya region is still surrounded by mystery. Recently, two purported yeti samples from the Himalayas showed genetic affinity with an ancient polar bear, suggesting they may be from previously unrecognized, possibly hybrid, bear species, but this preliminary finding has been under question...

A simple switch lets an appetite regulator linger
J. Am. Chem. Soc. (2017)
Thioamide Substitution Selectively Modulates Proteolysis and Receptor Activity of Therapeutic Peptide Hormones
Peptide hormones are attractive as injectable therapeutics and imaging agents, but they often require extensive modification by mutagenesis and/or chemical synthesis to prevent rapid in vivo degradation. Alternatively, the single-atom, O-to-S modification of peptide backbone thioamidation has the potential to selectively perturb interactions with proteases while preserving interactions with other proteins, such as target receptors...

Origami inspires artificial muscles
Proc. Natl Acad. Sci. USA (2017)
Fluid-driven origami-inspired artificial muscles
Artificial muscles are flexible actuators with capabilities similar to, or even beyond, natural muscles. They have been widely used in many applications as alternatives to more traditional rigid electromagnetic motors. Numerous studies focus on rapid design and low-cost fabrication of artificial muscles with customized performances. Here, we present an architecture for fluidic artificial muscles with unprecedented performance-to-cost ratio...
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