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This issue's Research Highlights (12-18 May 2017)
생명과학 BRIC (2017-05-18 14:54)
Research Highlights from the Nature

Microbiology
Why some drug-resistant bacteria thrive in hospitals
Cell (2017)
Tracing the Enterococci from Paleozoic Origins to the Hospital
We examined the evolutionary history of leading multidrug resistant hospital pathogens, the enterococci, to their origin hundreds of millions of years ago. Our goal was to understand why, among the vast diversity of gut flora, enterococci are so well adapted to the modern hospital environment...

Chemical biology
Small molecule shuttles iron into cells
Science (2017)
Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals
Multiple human diseases ensue from a hereditary or acquired deficiency of iron-transporting protein function that diminishes transmembrane iron flux in distinct sites and directions. Because other iron-transport proteins remain active, labile iron gradients build up across the corresponding protein-deficient membranes...

Biotechnology
Ancient protein resurrected in bacteria
Cell Rep. (2017)
Using Resurrected Ancestral Proviral Proteins to Engineer Virus Resistance
Proviral factors are host proteins hijacked by viruses for processes essential for virus propagation such as cellular entry and replication. Pathogens and their hosts co-evolve. It follows that replacing a proviral factor with a functional ancestral form of the same protein could prevent viral propagation without fatally compromising organismal fitness...

Immunology
Male hormones curb allergies in mice
J. Exp. Med. (2017)
Androgen signaling negatively controls group 2 innate lymphoid cells
Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have reduced numbers of ILC2 progenitors (ILC2Ps) and mature ILC2s in peripheral tissues compared with females...
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