[DEBUG-WINDOW 처리영역 보기]
즐겨찾기  |  뉴스레터  |  오늘의 정보 회원가입   로그인
BRIC홈 한국을 빛내는 사람들
BRIC Top5
스폰서배너광고 안내  배너1 배너2 배너3 배너4
전체보기 추천논문 상위피인용논문 인터뷰 그이후 한빛사통계
김상욱
김상욱 (Sanguk Kim) 저자 이메일 보기
POSTECH
 
조회 3526  인쇄하기 주소복사 트위터 공유 페이스북 공유 
Protein localization as a principal feature of the etiology and comorbidity of genetic diseases

Solip Park1, Jae-Seong Yang1, Young-Eun Shin2, Juyong Park3, Sung Key Jang1,2,4,5 and Sanguk Kim1,2,6,*

1 School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Korea, 2 Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Korea, 3 Physics Department, Kyung Hee University, Seoul, Korea, 4 Division of Integrative Bioscience and Biotechnology, Pohang University of Science and Technology, Pohang, Korea, 5 Biotechnology Research Center, Pohang University of Science and Technology, Pohang, Korea and 6 Division of IT Convergence Engineering, Pohang University of Science and Technology, Pohang, Korea

* Corresponding author. Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang 790-784, Korea. Tel.: +82 54 279 2348;Fax: +82 54 279 2199

Proteins targeting the same subcellular localization tend to participate in mutual protein.protein interactions (PPIs) and are often functionally associated. Here, we investigated the relationship between disease-associated proteins and their subcellular localizations, based on the assumption that protein pairs associated with phenotypically similar diseases are more likely to be connected via subcellular localization. The spatial constraints from subcellular localization significantly strengthened the disease associations of the proteins connected by subcellular localizations. In particular, certain disease types were more prevalent in specific subcellular localizations. We analyzed the enrichment of disease phenotypes within subcellular localizations, and found that there exists a significant correlation between disease classes and subcellular localizations. Furthermore, we found that two diseases displayed high comorbidity when disease-associated proteins were connected via subcellular localization. We newly explained 7584 disease pairs by using the context of protein subcellular localization, which had not been identified using shared genes or PPIs only. Our result establishes a direct correlation between protein subcellular localization and disease association, and helps to understand the mechanism of human disease
progression.

Molecular Systems Biology 7: 494; published online 24 May 2011; doi:10.1038/msb.2011.29
Subject Categories: metabolic and regulatory networks; molecular biology of disease
Keywords: cellular networks; comorbidity; human disease; subcellular localization

논문정보
- 형식: Research article
- 게재일: 2011년 05월 (BRIC 등록일 2011-05-25)
- 연구진: 국내연구진태극기
- 분야: Systems Biology
관련 보도자료
  댓글 0
등록
 
목록
코리아바이오믹스
관련링크
김상욱 님 전체논문보기 >
관련인물
김은정 (POSTECH)
김인해 (POSTECH)
김종경 (EMBL-EBI)
김진호 (삼성서울병원)
박솔잎 (EMBL/Center for Genomic R...)
서상우 (Seoul National University)
양재성 (POSTECH)
이동욱 (POSTECH)
이승재 (POSTECH)
이윤태 (POSTECH)
정규열 (POSTECH)
한성규 (POSTECH)
황인환 (POSTECH)
관련분야 논문보기
Systems Biology

외부링크
Google (by Sanguk Kim)
Pubmed (by Sanguk Kim)
프리미엄 Bio일정 Bio일정 프리미엄 안내
바이오 QC 실무과정 6기 모집
바이오 QC 실무과정 6기 모집
사전접수: ~2019.01.07
날짜: 2019.03.04~12.09
장소: 성남시 분당구 황새울로 329번길 5
임상시험종사자 생체시료분석법 이해, 생물학적동등성시험의 이해
임상시험종사자 생체시료분석법 이해, 생물학적동등성시험의 이해
사전접수: ~2018.12.20
날짜: 2018.12.20~21
장소: 한국제약바이오협회 강의장 / 이매스교육센터
위로가기
한빛사 홈  |  한빛사FAQ  |  한빛사 문의 및 제안
 |  BRIC소개  |  이용안내  |  이용약관  |  개인정보처리방침  |  이메일무단수집거부
Copyright © BRIC. All rights reserved.  |  문의 member@ibric.org
트위터 트위터    페이스북 페이스북    RSS서비스 RSS
에펜도르프코리아