[DEBUG-WINDOW 처리영역 보기]
BRIC을 시작페이지로 회원가입    로그인
배너1 배너2 배너3 스폰서배너광고 안내
오늘의 BRIC정보
트위터 페이스북
검색 뉴스레터 안내
좋은 연구문화 만들기
Bio일정 프리미엄(유료) 등록이란?
2016년 10월달 Bio일정을 확인하세요.
Biojob 프리미엄(유료) 등록이란?
대메뉴안내: 동향
뉴스 Bio통신원 Bio통계 BRIC View BRIC이만난사람들 웹진
추천22  조회10281  소셜네트워크로 공유하기
 BioWave, Vol.12, No.5, SubNo.3
Tet-Off Conditional Transgenic Approaches in Modeling Parkinson's Disease in Mice

Johns Hopkins University

To whom correspondence should be addressed. E-mail : ylee69(at).jhmi.edu

Parkinson's disease (PD) is the most common neurological movement disorder characterized by the dysfunctional nigrostriatal dopaminergic pathway majorly due to the progressive loss of dopamine producing neurons in the substantia nigra pas compacta (SNpc) of midbrain. The degeneration in this circuit is responsible for PD-linked clinical symptoms of movement deficit including slow movement, tremor, rigidity and postural instability because dopamine transmission in nigrostriatal pathway is crucial in controlling muscle movement and balance. Besides, the progressive loss of motor control is often accompanied by secondary non-motor symptoms which are associated with PD and sometimes more debilitating to the affected patients. They include pain, constipation, depression, anxiety, dementia and sweating. In the degenerating environment of SN, intracellular protein deposits, termed Lewy bodies, which are majorly composed of α-synuclein (α-syn), are easily found and indeed used as a pathological hallmark for PD (Lang and Lozano 1998; Lang and Lozano 1998). Considering the prevalence of disease, with more than 1 million people affected in North America with ever increasing rate due to extended lifespan (Lang and Lozano 1998), and no cure except for the anti-symptomatic medications of dopamine supplementation (i.e., L-DOPA plus carbidopa regimen), it cannot be more emphasized to understand the underlying mechanisms by which the degeneration and biochemical alterations are initiated and progress, which can ultimately prompt the development of therapeutic strategies. Since we have ponderous background knowledge about the functions of genes which are linked to PD in cell system and in vitro (Moore, West et al. 2005), the next step and focus should be given to validating the pathways in in vivo mouse system and further testing potential chemicals or disease modifying genes in PD animal model.

JHIBRG Home Page

Category : Medicine
(이 자료는 BRIC IP Johns Hopkins Interdisciplinary Biomedical Research Group에서 제공하였습니다.)
Citation: 이연종(2010). Tet-Off Conditional Transgenic Approaches in Modeling Parkinson's Disease in Mice. BioWave, 12(5): 3. Available from http://www.ibric.org/myboard/read.php?Board=review0&id=2701 (May 04, 2010)
성균관대 의과대학
성균관대 의과대학 스폰서배너광고 안내
  년도별/분야별 보기
  Review by 이연종 더보기  
Systemic and cell-type specific profiling of molecular changes in Parkinson's disease
Mitochondrial Biology in Parkinson’s Disease
  PDF Reader 설치 다운로드
  이달의 웹진
이달의 웹진   BRIC View
이전페이지로 돌아가기 맨위로 가기

BRIC 홈    BRIC 소개    회원    검색    문의/FAQ    광고
Copyright © BRIC. All rights reserved. Contact member@ibric.org